.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 3,854,480

« Back to Dashboard

Details for Patent: 3,854,480

Title: DRUG-DELIVERY SYSTEM
Abstract:Drug-delivery system for releasing drug at a controlled rate for a prolonged period of time is formed from a solid inner matrix material having solid particles of drug dispersed therethrough. Surrounding the inner matrix is an outer polymeric membrane, insoluble in body fluids. Both the inner matrix material and the outer polymeric membrane are permeable to passage of the drug by diffusion but the drug diffuses through the outer polymeric membrane at a lesser rate so that passage through the polymeric membrane is the drug release rate controlling step.
Inventor(s): Zaffaroni; Alejandro (Atherton, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Filing Date:Jun 02, 1970
Application Number:05/042,786
Claims:1. A drug-delivery system for the continuous and controlled administration of drug to a body comprising in combination:

a. a solid inner matrix material having solid particles of said drug dispersed therethrough, said inner matrix being permeable to passage of said drug by diffusion; and

b. an outer polymeric membrane, insoluble in body fluids, surrounding said inner matrix, said polymeric membrane characterized by being formed of a drug release rate controlling material which is permeable to passage of said drug by diffusion but at a rate which is lower than through said inner matrix material,

c. and wherein the system is so constructed and arranged that when placed in the environment of use, the outer polymeric membrane continuously meters the flow of drug from the inner matrix material to the exterior of the system at a controlled and constant rate over a prolonged period of time.

2. The drug-delivery system of claim 1 wherein said inner matrix material is silicone rubber.

3. A drug-delivery system for the continuous and controlled administration of drug to a body comprising in combination:

a. an inner mass transfer conductor material saturated with dissolved drug and additionally having solid particles of said drug dispersed therethrough, said inner material being permeable to passage of said drug by diffusion;

b. a polymeric membrane, insoluble in body fluids, surrounding said inner mass transfer conductor material, said polymeric membrane being permeable to passage of said drug by diffusion but at a lower rate than the rate of diffusion of drug through said inner mass transfer conductor material, and

c. wherein the system is so constructed and arranged that when placed in the environment of use, the outer polymeric membrane continuously meters the flow of drug from the inner mass transfer conductor material to the exterior of the system at a controlled and constant rate over a prolonged period of time.

4. The drug-delivery system of claim 3 wherein said polymeric membrane is an ethylene-vinyl acetate copolymer.

5. The drug-delivery system of claim 3 wherein said drug is progesterone.

6. The drug-delivery system of claim 3 wherein said polymeric membrane is polyethylene.

7. The drug-delivery system of claim 4 wherein said drug is progesterone.

8. The drug-delivery system of claim 3 wherein the polymeric membrane is selected from the group consisting of plasticized or unplasticized polyvinylchloride.

9. The drug-delivery system of claim 3 wherein said drug is progesterone.

10. A drug-delivery system for the continuous and controlled administration of drug to a body comprising in in combination:

a. a solid inner matrix material having solid particles of said drug dispersed therethrough, said inner matrix being permeable to passage of said drug by diffusion; and

b. an outer polymeric membrane, insoluble in body fluids, surrounding said inner matrix, said polymeric membrane characterized by being formed of a drug release rate controlling material which is permeable to passage of said drug by diffusion but at a rate which is not more than one half said drug's rate of diffusion through said inner matrix material, and

c. wherein the system is so constructed and arranged that when placed in the environment of use, the outer polymeric membrane continuously meters the flow of drug from the inner matrix material to the exterior of the system at a controlled and constant rate over a prolonged period of time.

11. A drug-delivery system for the continuous and controlled administration of drug to a body comprising in combination:

a. a solid inner matrix material having solid particles of said drug dispersed therethrough, said inner matrix being permeable to passage of said drug by diffusion; and

b. an outer polymeric membrane, insoluble in body fluids, surrounding said inner matrix, said polymeric membrane characterized by being formed of a drug release rate controlling material which is permeable to passage of said drug by diffusion but at a rate which is not more than one tenth said drug's rate of diffusion through said inner matrix material, and

c. wherein the system is so constructed and arranged that when placed in the environment of use, the outer polymeric membrane continuously meters the flow of drug from the inner matrix material to the exterior of the system at a controlled and constant rate over a prolonged period of time.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc