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Details for Patent: 3,852,337

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Details for Patent: 3,852,337

Title: PGF TETRAOLS AND ALKANOYL ESTERS
Abstract:There are disclosed compounds of the formula: ##SPC1## Wherein Y is --CH.sub.2 CH.sub.2 -- or trans--CH=CH--, and both X and Z are --CH.sub.2 CH.sub.2 --, or wherein Y is trans--CH=CH--, X is cis--CH=CH--, and Z is --CH.sub.2 CH.sub.2 -- or cis--CH=CH--, wherein R is hydrogen or lower alkanoyl, and wherein .about. indicates attachment of --OR to the ring in alpha or beta configuration. These novel compounds are useful for a variety of pharmacological purposes, including use as smooth muscle stimulants.
Inventor(s): Bergstrom; Sune (Stockholm 60, SW), Sjovall; Jan (Stockholm 60, SW)
Assignee:
Filing Date:Aug 23, 1972
Application Number:05/282,952
Claims:1. A compound of the formula: ##SPC6##

wherein Y is --CH.sub.2 CH.sub.2 -- or trans--CH=CH--, and both X and Z are --CH.sub.2 CH.sub.2 --, or wherein Y is trans--CH=CH--, X is cis--CH=CH--, and Z is --CH.sub.2 CH.sub.2 -- or cis--CH=CH--, wherein R is hydrogen or lower alkanoyl, all R groups being the same, and wherein .about. indicates attachment of --OR to the ring in alpha or beta configuration.

2. A compound according to claim 1 wherein .about. indicates an alpha attachment of --OR to the ring.

3. A compound according to claim 1 wherein .about. indicates a beta attachment of --OR to the ring.

4. A compound according to claim 2 wherein X, Y, and Z are --CH.sub.2 CH.sub.2 --.

5. A compound according to claim 4 wherein all R are hydrogen.

6. A compound according to claim 4 wherein all R are acetyl.

7. A compound according to claim 2 wherein Y is trans--CH=CH--, and X and Y are --CH.sub.2 CH.sub.2 --.

8. A compound according to claim 7 wherein all R are hydrogen.

9. A compound according to claim 7 wherein all R are acetyl.

10. A compound according to claim 2 wherein Y is trans--CH=CH--, X is cis--CH=CH--, and Z is --CH.sub.2 CH.sub.2 --.

11. A compound according to claim 10 wherein all R are hydrogen.

12. A compound according to claim 10 wherein all R are acetyl.

13. A compound according to claim 2 wherein Y is trans--CH=CH--, and X and Z are cis--CH=CH--.

14. A compound according to claim 13 wherein all R are hydrogen.

15. A compound according to claim 13 wherein all R are acetyl.

16. A compound according to claim 3 wherein X, Y, and Z are --CH.sub.2 CH.sub.2 --.

17. A compound according to claim 16 wherein all R are hydrogen.

18. A compound according to claim 16 wherein all R are acetyl.

19. A compound according to claim 3 wherein Y is trans--CH=CH--, and X and Z are --CH.sub.2 CH.sub.2 --.

20. A compound according to claim 19 wherein all R are hydrogen.

21. A compound according to claim 19 wherein all R are acetyl.

22. A compound according to claim 3 wherein Y is trans--CH=CH--, X is cis--CH=CH--, and Z is --CH.sub.2 CH.sub.2 --.

23. A compound according to claim 22 wherein all R are hydrogen.

24. A compound according to claim 22 wherein all R are acetyl.

25. A compound according to claim 3 wherein Y is trans--CH=CH--, and X and Z are cis--CH=CH--.

26. A compound according to claim 25 wherein all R are hydrogen.

27. A compound according to claim 25 wherein all R are acetyl.
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