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US Army
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Chinese Patent Office
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Mallinckrodt
Moodys

Generated: May 24, 2018

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Details for Patent: 3,843,681

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Title: 1-CARBOXAMIDO PYRANO (THIOPYRANO) [3,4-6]INDOLE DERIVATIVES
Abstract:Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.
Inventor(s): Demerson; Christopher A. (St. Laurent, Quebec, CA), Humber; Leslie G. (Dollard des Ormeaux, Quebec, CA), Dobson; Thomas A. (Dollard des Ormeaux, Quebec, CA), Jirkovsky; Ivo L. (Montreal, Quebec, CA)
Assignee: American Home Products Corporation (New York, NY)
Filing Date:Jun 01, 1971
Application Number:05/148,895
Claims:1. A compound of the formula: ##SPC37##

wherein R.sup.1 is lower alkyl having from one to six carbon atoms; R.sup.6 is hydrogen, chlorine, methyl, methoxy or benzyloxy; R.sup.7 is hydrogen or lower alkyl having from one to six carbon atoms; X is oxygen or sulfur; Y is CO, CH.sub.2 CO or CH.sub.2 CH.sub.2 CO; and Z is amino, methylamino, ethylamino, isopropylamino, dimethylamino, diethylamino or phenylamino.

2. A compound of the formula: ##SPC38##

wherein R.sup.1 is lower alkyl having from one to six carbon atoms; Y is CO, CH.sub.2 O, CH.sub.2 CH.sub.2 CO; and Z is amino, methylamino, ethylamino, isopropylamino, dimethylamino, diethylamino or phenylamino.

3. N,N,1-Trimethyl-1,3,4,9-tetrahydropyrano[3,4-b]-indole-1-acetamide, as claimed in claim 2.

4. 1-Methyl-1,3,4,9-tetrahydropyrano[3,4-b]-indole-1-acetamide, as claimed in claim 2.

5. N,1-Dimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetamide, as claimed in claim 2.

6. N-Phenyl-1-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetamide, as claimed in claim 2.

7. N,1-Dimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-propionamide, as claimed in claim 2.

8. 1-Methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-carboxamide, as claimed in claim 2.

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Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
Johnson and Johnson
Teva
Baxter
Federal Trade Commission
McKesson
Citi
Cantor Fitzgerald
US Army

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