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Details for Patent: 3,797,494

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Details for Patent: 3,797,494

Title: BANDAGE FOR THE ADMINISTRATION OF DRUG BY CONTROLLED METERING THROUGH MICROPOROUS MATERIALS
Abstract:A bandage for use in the continuous administration of drugs to the skin or mucosa, comprising a backing member defining one exterior surface, a surface of pressure-sensitive adhesive defining a second exterior surface, and disposed therebetween a reservoir containing drug formulation confined therein. The reservoir can comprise a distinct layer of the bandage or a plurality of microcapsules distributed throughout the adhesive surface, and in either case the drug can be confined within an interior chamber of the reservoir or distributed throughout a reservoir matrix. The drug passes through drug release rate controlling microporous material which continuously meters the flow of drug by viscous or diffusive transfer to the skin or mucosa at a controlled and predetermined rate over a period of time.
Inventor(s): Zaffaroni; Alejandro (Atherton, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Filing Date:Aug 09, 1971
Application Number:05/169,976
Claims:1. A medical bandage for the continuous administration of controlled quantities of drug to the skin or mucosa, comprised of a laminate of: (1) a backing member; bearing (2) a discrete middle reservoir layer containing a drug confined within a body, the body being comprised of drug release rate controlling microporous material permeable to the passage of drug, to continuously meter the flow of a therapeutically effective amount of the drug to the skin or mucosa from the reservoir at a controlled and predetermined rate over a period of time; and (3) a pressure-sensitive adhesive surface adapted for contact with the skin or mucosa and postitioned on one surface of the reservoir remote from the backing member.

2. The bandage as defined by claim 1 wherein the pores of the microporous rate controlling material are filled with a medium to permit controlled diffusion of the drug from the reservoir.

3. A medical bandage for the continuous administration of controlled quantities of drug to the skin or mucosa, comprised of a laminate of: (1) a backing member; bearing (2) a discrete middle reservoir containing a drug confined therein, the reservoir being formed of material permeable to passage of the drug; and (3) a pressure-sensitive adhesive surface adapted for contact with the skin or mucosa and positioned on one surface of the reservoir remote from the backing member and wherein one or more drug release rate controlling microporous membranes are interposed between the surface of the reservoir and pressure-sensitive adhesive so as to continuously meter the flow of a therapeutically effective amount of the drug from the reservoir at a controlled and predetermined rate over a period of time.

4. The bandage as defined by claim 3 wherein the reservoir is a container having the drug confined therein.

5. The bandage as defined by claim 4 wherein the reservoir is pressurized to permit controlled microporous flow of the drug from the reservoir.

6. The bandage as defined by claim 3 wherein the reservoir is a solid or microporous matrix having the drug dispersed therein.

7. The bandage as defined by claim 3 wherein the pores of the microporous rate controlling material are filled with a medium to permit controlled diffusion of the drug from the reservoir.
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