Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Covington
Julphar
Dow
Medtronic
US Army
Express Scripts
Boehringer Ingelheim
Citi
Fish and Richardson

Generated: April 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 3,759,987

« Back to Dashboard

Title: PREPARATION OF 5-FLUORO-2-METHYL-1-(P-METHYLSULFINYLBENZYLIDENE)-3-INDENYL ACETIC ACID
Abstract:Process for preparing 1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acids by introducing a methylsulfinyl group into a 1-benzylidene-3-indenyl acetic acid.
Inventor(s): Conn; John B. (Westfield, NJ), Bollinger; Frederick W. (Westfield, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:May 01, 1970
Application Number:05/033,974
Claims:1. A process wherein a compound of the formula: ##SPC8##

wherein E is hydrogen, lower alkyl or quaternary ammonium base, is

a. diazotized to a diazonium compound;

b. said diazonium compound is treated with sulfur dioxide to form a sulfinic acid compound;

c. said sulfinic acid compound is treated with a chlorinating agent to form the corresponding chlorosulfinyl compound;

d. said chlorosulfinyl compound is esterified to form the corresponding ester;

e. said ester is treated with a alkyl magnesium halide followed by addition of an aqueous acid to form the 3-indenyl acetone compound; and

f. converting said 3-indenyl acetone compound to 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid by the haloform reaction.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Colorcon
Federal Trade Commission
QuintilesIMS
McKinsey
Deloitte
Fuji
US Department of Justice
Moodys
Dow

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.