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|Title:||N-ACYL-.alpha.-HYDRAZINO-HYDROCINNAMIC ACID AND DERIVATIVES|
|Abstract:||Diastereomers of N-acyl .alpha.-hydrazino-.beta.-(substituted or unsubstituted phenyl)alkanoic acid derivatives which can be separated and hydrolyzed to give compounds useful as decarboxylase inhibitors.|
|Inventor(s):||Karady; Sandor (Elizabeth, NJ), Pines; Seemon H. (Murray Hill, NJ), Ly; Manuel G. (New Brunswick, NJ), Sletzinger; Meyer (North Plainfield, NJ)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
|Filing Date:||Jun 24, 1971|
|Claims:||1. A compound of the formula ##SPC10## |
R is an unsubstituted phenyl radical, a 3-substituted phenyl radical, a 4-substituted phenyl radical or a 3,4-disubstituted phenyl radical wherein the substituents are hydroxy or lower alkoxy, phenyloxy or benzyloxy;
R.sub.1 is hydrogen or lower alkyl;
R.sub.2 is -COOH; and
R.sub.3 is an acyl radical containing less than about 30 carbon atoms and having at least one asymmetric carbon atom, the acyl radical being predominantly in either the d or l form and being derived from a carboxylic or a sulfonic acid.
2. The compound of claim 1 wherein R is a 3,4-disubstituted phenyl radical.
3. The compound of claim 1 wherein R.sub.1 is hydrogen.
4. The compound of claim 1 wherein R.sub.1 is methyl.
5. The compound of claim 1 wherein R.sub.3 is the menthoxyacetyl radical.