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Details for Patent: 3,734,097

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Details for Patent: 3,734,097

Title: THERAPEUTIC ADHESIVE TAPE
Abstract:Adhesive laminate tape for the topical administration of controlled therapeutically effective quantities of drug selected from the group consisting of anti-neoplastic agents, folic acid antagonists and anit-mitotic agents for the treatment of skin lesions, comprising a backing member bearing a pressure-sensitive adhesive, the adhesive having distributed therein a means for metering the flow of a therapeutically effective amount of the drug to the lesions over a prolonged period of time.
Inventor(s): Zaffaroni; Alejandro (Atherton, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Filing Date:Apr 23, 1971
Application Number:05/136,981
Claims:1. A therapeutic adhesive tape for the topical administration of controlled quantities of drug for the treatment of skin lesions, said tape comprising a laminate of (1) a backing member bearing (2) a pressure-sensitive adhesive on one surface thereof adapted for contact with the skin, said pressure-sensitive adhesive having distributed therethrough (3) a plurality of discreet microcapsules, each of which microcapsules comprise a therapeutic agent selected from the group consisting of an anti-neoplastic agent and a folic acid antagonist confined within a wall member, the wall member being formed from drug release rate controlling material to continuously meter the flow of a therapeutically effective amount of the therapeutic agent to the skin lesions from the microcapsules at a controlled and predetermined rate over a period of time.

2. The therapeutic adhesive tape of claim 1 wherein said microcapsules (3) comprise a matrix of the drug release rate controlling wall material, said matrix having the therapeutic agent distributed therethrough.

3. The therapeutic adhesive tape of claim 1 wherein said microcapsules (3) comprise the therapeutic agent microencapsulated within the drug release rate controlling wall material.

4. The therapeutic adhesive tape of claim 1 wherein said folic acid antagonist is selected from the group consisting of methotrexate, aminopterin, 3'-chloromethotrexate and 3', 5'-dichloromethotrexate.

5. The therapeutic adhesive tape of claim 1 wherein said anti-neoplastic agent is selected from the group consisting of vincristine, vinblastine, 5-fluorouracil, 5-fluorodeoxyuridine and 6-mercotopurine.

6. The therapeutic adhesive tape of claim 1 wherein said therapeutic agent is methotrexate present at a concentration of 0.01 to 100 micrograms of methotrexate per sq. cm. of surface of pressure-sensitive adhesive coating.

7. The therapeutic adhesive tape of claim 1 further containing an anti-inflammatory steroid.

8. A therapeutic adhesive tape for the topical administration of controlled quantities of drug for the treatment of skin lesions, said tape comprising a laminate of (1) a backing member; (2) a discrete middle reservoir layer containing a therapeutic agent selected from the group consisting of an anti-neoplastic agent and a folic acid antagonist confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of a therapeutically effective amount of the therapeutic agent to the skin lesions from the reservoir at a controlled and predetermined rate over a period of time; and (3) a pressure-sensitive adhesive surface adapted for contact with the skin and positioned on one wall of the reservoir remote from the backing member.

9. The therapeutic adhesive tape of claim 8 where the reservoir layer (2) comprises a walled container having an interior chamber containing the therapeutic agent.

10. The therapeutic adhesive tape of claim 8 wherein the reservoir layer (2) comprises a matrix of the drug release rate controlling wall material, said matrix having the therapeutic agent distributed therethrough.

11. The therapeutic adhesive tape of claim 8 further including a solubility membrane interposed between said reservoir and said pressure-sensitive adhesive coating.

12. The therapeutic adhesive tape of claim 8 wherein said folic acid antagonist is selected from the group consisting of methotrexate, aminopterine, 3'-chloromethotrexate and 3', 5'-dichloromethotrexate.

13. The pressure-sensitive adhesive tape of claim 8 wherein said anti-neoplastic agent is selected from the group consisting of vincristine, vinblastine, 5-fluorouracil, 5-fluorodexyuridine, and 6-mercoptopurine.

14. The therapeutic adhesive tape of claim 8 wherein said therapeutic agent is methotrexate.

15. The therapeutic adhesive tape of claim 8 wherein said therapeutic agent is methotrexate present at a concentration of 0.01 to 100 micrograms of methotrexate per sq. cm. of surface of pressure-sensitive adhesive coating.

16. The therapeutic adhesive tape of claim 8 further including an anti-inflammatory steroid.
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