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Details for Patent: 3,731,683

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Details for Patent: 3,731,683

Title: BANDAGE FOR THE CONTROLLED METERING OF TOPICAL DRUGS TO THE SKIN
Abstract:Bandage for the topical administration of controlled therapeutically effective quantities of topically active drugs has a backing member, a pressure-sensitive adhesive, and a reservoir layer containing a topically active drug confined within a wall member. The wall member is formed from drug release rate controlling material to continuously meter the flow of a therapeutically effective amount of the drug through the wall to the skin at a controlled and predetermined rate over a period of time.
Inventor(s): Zaffaroni; Alejandro (Atherton, CA)
Assignee: Alza Corporation (N/A)
Filing Date:Jun 04, 1971
Application Number:05/150,085
Claims:1. A medical bandage for the continuous administration to the skin or mucosa of controlled quantities of topically active drugs over a prolonged period of time, said bandage comprising a laminate of (1) a backing member defining one face surface of the bandage; (2) a pressure-sensitive adhesive adapted for contact with the skin or mucosa, the external surface of said pressure-sensitive adhesive defining the other face surface of the bandage and disposed between the face surfaces defined by (1) and (2); (3) at least one reservoir comprised of a topically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drug from the said reservoir to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time.

2. The medical bandage of claim 1, wherein said bandage comprises a laminate of: (1) a backing member; bearing (2) a pressure-sensitive adhesive on one surface thereof adapted for contact with the skin, said pressure-sensitive adhesive having distributed therethrough; (3) a plurality of discrete microcapsules, each of which microcapsules comprises a topically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of a therapeutically effective amount of the drug in the skin through the wall of said microcapsules at a controlled and predetermined rate over a period of time.

3. The bandage as defined by claim 2, wherein each of said microcapsules (3) is comprised of topically active drug formulation microencapsulated with the drug release rate controlling material.

4. The bandage as defined by claim 2, wherein each of said microcapsules (3) is comprised of a matrix of the drug release rate controlling wall material, said matrix having the topically active drug formulation distributed therethrough.

5. The bandage as defined by claim 2, wherein the drug formulation includes a pharmacologically acceptable solvent.

6. The medical bandage of claim 1, wherein said bandage comprises a laminate of: (1) a backing member; bearing (2) a discrete, middle reservoir layer, which reservoir layer is comprised of topically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of a therapeutically effective amount of the drug to the skin through the wall at a controlled and predetermined rate over a period of time; and (3) a pressure-sensitive adhesive adapted for contact with the skin and carried by the reservoir remote from the backing member.

7. The bandage as defined by claim 6, wherein the reservoir layer (2) is comprised of a walled container having an interior chamber containing the topically active drug formulation.

8. The bandage as defined by claim 6, wherein the reservoir layer (2) is comprised of a matrix of the drug release rate controlling wall material, said matrix having the topically active drug formulation distributed therethrough.

9. The bandage as defined by claim 6, wherein the drug formulation includes a pharmacologically acceptable solvent.

10. The bandage as defined by claim 6, further comprising a solubility membrane (4) interposed between said reservoir layer (2) and said surface of pressure-sensitive adhesive (3). 11. The bandage as defined by claim

2, wherein the rate release controlling material is silicone rubber. 12. The bandage as defined by claim 6, wherein the rate release

controlling material is silicone rubber. 13. The bandage as defined by claim 2, wherein the rate release controlling material is a hydrophilic

polymer of an ester of an olefinic acid. 14. The bandage as defined by claim 6, wherein the rate release controlling material is a hydrophilic polymer of an ester of an olefinic acid.
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