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Details for Patent: 3,718,674

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Details for Patent: 3,718,674

Title: DIASTEREOMERS OF .alpha.-HYDRAZINO-.beta.-(PHENYL)PROPIONITRILES
Abstract:Diastereomers of and a method of resolving .alpha.-hydrazino-.beta.-(substituted or unsubstituted phenyl)alkanoic acid derivatives.
Inventor(s): Karady; Sandor (Elizabeth, NJ), Pines; Seemon H. (Murray Hill, NJ), Ly; Manuel G. (Edison, NJ), Sletzinger; Meyer (North Plainfield, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Jun 24, 1970
Application Number:05/049,542
Claims:1. A diastereomer of a compound of the formula

wherein

R is a 3,4-disubstituted phenyl radical wherein the substituents are carbobenzyloxy and carboalkoxy;

R.sub.1 and R.sub.2 are hydrogen or lower alkyl;

R.sub.3 is --CN; and

R.sub.4 and R.sub.5 are hydrogen, benzoyl or lower alkanoyl with at least one group being hydrogen

with an optically active acid.

2. A diastereomer of a compound of the formula

wherein

R is a 3,4-disubstituted phenyl radical wherein the substituents are carbobenzyloxy and carboalkoxy;

R.sub.1 and R.sub.2 are hydrogen or lower alkyl;

R.sub.3 is --CN; and

R.sub.4 and R.sub.5 are hydrogen, benzoyl or lower alkanoyl with at least one group being hydrogen

with an optically active acid selected from the group consisting of camphoric acid, camphorsulfonic acid, dibenzoyltartaric acid, ditolyltartaric acid, malic acid, pyroglutamic acid, .alpha.-methyl-.alpha.-phenylacetic acid, atrolactic, menthoxyacetic acid and cholic acid.

3. The diastereomer of claim 2 in the crystalline form.

4. The diastereomer of claim 2 wherein the compound of the structural formula is in the L-stereo configuration.
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