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|Title:||CERTAIN BENZYLHYDRAZINO DERIVATIVES OF LOWER-ALKYL SUBSTITUTED UREAS|
|Abstract:||Benzene-ring substituted (2-methylhydrazino)-methyl-benzene compounds and intermediates therefore are described. The former compounds are useful as cytostatic agents and, particularly, inhibit the growth of transplantable tumors in both mice and rats. Thus, they are active, for example, against Walker tumors, Ehrlich carcinoma and Ehrlich ascites carcinoma.|
|Inventor(s):||Bollag; Werner (Basel, CH), Gutmann; Hugo (Reinach/Baseland, CH), Hegedus; Balthasar (Binningen, CH), Kaiser; Ado (Neufrenkendorf, CH), Langemann; Albert (Binningen, CH), Muller; Marcel (Frenkendorf, CH), Zeller; Paul (Allschwil, CH)|
|Assignee:||Hoffmann-LaRoche Inc. (Nutley, NJ)|
|Filing Date:||Jun 04, 1970|
|Claims:||1. A compound selected from the group consisting of compounds of the formula ##SPC6## |
and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.8 is hydrogen R.sub.9 is selected from the group consisting of, carbamoyl, lower alkylcarbamoyl and hydroxy-lower alkylcarbamoyl.
2. A compound in accordance with claim 1, wherein R.sub.8 is hydrogen and R.sub.9 is carbamoyl.
3. A compound in accordance with claim 1, wherein R.sub.8 is hydrogen and R.sub.9 is lower alkylcarbamoyl.
4. A compound as in claim 1 which is 1-methyl-2-(4-ureido-benzyl)-hydrazine.
5. A compound as in claim 1 which is 1-methyl-2-[4-(3-n-butyl-ureido)-benzyl]-hydrazine.
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