|Title:||PGE METHYL ESTER AND PGE METHYL ESTER DIACETATE|
|Abstract:||The prostaglandins PGE.sub.2 methyl ester and PGE.sub.2 methyl ester diacetate are disclosed. These novel compounds are useful for a variety of pharmacological purposes, including use as smooth muscle stimulants and as cardiovascular agents. 3 Claims, No Drawings|
|Inventor(s):||Sune Bergstrom (Kemiska Institutionen, Karulinska), Institutet (Stockholm 60, SE), Jan Sjovall, Kemiska Institutionen (Karulinska Institutet), Stockholm 60, SE (N/A)|
|Filing Date:||Feb 12, 1971|
|Claims:||1. A compound of the formula: wherein R.sub.1 is hydrogen or acetyl, said compound being essentially free |
2. A compound according to claim 1 wherein both R.sub.1 are hydrogen, said compound being the methyl ester of 7-[3.alpha.-hydroxy-2.beta.-[(3S)- 3-hydroxy-trans-1-octenyl]-5-oxo-1.alpha
3. A compound according to claim 1 wherein both R.sub.1 are acetyl, said compound being the methyl ester diacetate of 7-[3.alpha.-hydroxy-2.beta.- [3S)-3-hydroxy-trans-1-octenyl]-5-oxo-1.alpha.-cyclopentyl]-cis-5- heptenoic acid.