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Details for Patent: 3,686,320

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Details for Patent: 3,686,320

Title: BIS-PHENOXY COMPOUNDS
Abstract:Compounds of the formula wherein Z and Z' are hydroxy and Y and Y' are H, --COCH.sub.3, or --COOR' (R' being an alkyl group) are used to prepare compounds of the formula and therapeutically acceptable salts, esters and amides thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and each is H or halogen, lower alkyl, hydroxy, lower alkoxy, substituted lower alkyl or substituted lower alkoxy, and X is a saturated or unsaturated, substituted or unsubstituted, straight or branched polymethylene chain which may be interrupted by one or more carbocyclic rings or oxygen-containing heterocyclic rings, oxygen atoms or carbonyl groups. The latter compounds are useful as inhibitors of certain antigen-antibody reactions, being particularly useful for the relief and prophylaxis of asthma.
Inventor(s): Fitzmaurice; Colin (Cheshire, EN), Lee; Thomas Brian (Cheshire, EN)
Assignee: Fisons Pharmaceuticals Limited (Loughborough, EN)
Filing Date:Sep 25, 1968
Application Number:04/762,638
Claims:1. A compound of the formula

in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxylower alkyl, haloloweralkyl, hydroxyloweralkoxy, and loweralkoxyloweralkoxy and X is selected from the group consisting of straight and branched, saturated and unsaturated hydrocarbon chains which are uninterrupted or interrupted by a member selected from the group consisting of benzene, oxygen and carbonyl and are unsubstituted or substituted by a member of the group consisting of halogen or hydroxy and lower alkoxy, with the proviso that when R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are hydrogen, X is not the group --CH.sub.2 --CHOH--CH.sub.2 -- linking the two positions para to the acetyl groups.

2. A compound of the formula

in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxylower alkyl, haloloweralkyl, hydroxyloweralkoxy, and loweralkoxyloweralkoxy, and X represents a saturated hydrocarbon chain which is unsubstituted or which is substituted by a member of the group consisting of halogen, hydroxy or lower alkoxy with the proviso that when R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are hydrogen, X is not a group --CH.sub.2 --CHOH--CH.sub.2 -- linking the two positions para to the acetyl groups.

3. A compound according to claim 2 wherein X represents the group

4. A compound according to claim 3, said compound being 1,3-bis(2-acetyl-3-hydroxyphenoxy)-2-hydroxypropane.
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