|Title:||BASICALLY SUBSTITUTED HETEROCYCLES AS ANTI-EMETICS|
|Abstract:||Certain 11-basically substituted dibenz[b,f][1,4]oxazepines are useful as anti-emetics. 3 Claims, No Drawings|
|Inventor(s):||Jean Schmutz, Pourtalesstrasse 36 (Muri, CH), Fritz Hunziker, Wabernstrasse 53 (Berne, CH), Franz Martin Kunzle, Landoltstrasse 11 (Berne, CH)|
|Filing Date:||Jul 16, 1970|
|Claims:||1. A method for treating emesis, which comprises enterally or parenterally administering to a mammal in need of said treatment a compound of the formula: ##SPC4## and pharmaceutically acceptable acid addition salts thereof where R.sub.1 represents hydrogen, allyl, alkyl containing not more than three carbon atoms, hydroxyalkyl containing not more than three carbon atoms, alkoxyalkyl containing not more than six carbon atoms or alkoyloxy-alkyl containing not more than six carbon atoms and R.sub.2 and R.sub.3 are the same or different and represent hydrogen or methyl, at a daily dosage of |
2. A method according to claim 1 in which the compound is 2-dimethylaminosulphonyl-11-(4-methyl-1-piperazinyl)- dibenz[b,f][1,4]oxaze
3. A method according to claim 1 wherein the compound is administered to a mammal in need of said treatment in a unit dosage form comprising said compound to the extent of from about 10 milligrams to about 25 milligrams per unit dosage.
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