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|Title:||2-FORMYL-(6-METHOXY-2-NAPHTHYL) ACETIC ACID|
|Abstract:||2-(6-Methoxy-2-naphthyl)propionic acid is prepared by reacting a compound having the formula with hydrogen in the presence of a hydrogenation catalyst until a 2-(6-methoxy-2-naphthyl)propionate is formed, and hydrolyzing the ester group of the propionate. In the formula, R.sup.1 is an alkyl, cycloalkyl, aralkyl or alkenyl group and R.sup.2 is --OR.sup.3, --SR.sup.3, wherein R.sup.3, R.sup.5 and R.sup.6 each is alkyl or cycloalkyl; R.sup.4 is alkyl, cycloalkyl, aryl or aralkyl; and R.sup.5 and R.sup.6 together can be ethylene or a polymethylene group having from three to seven carbons. The product has anti-inflammatory, analgesic, and anti-pyretic activities.|
|Inventor(s):||Nelson; Peter H. (Los Altos, CA)|
|Assignee:||Syntex Corporation (Panama, PM)|
|Filing Date:||Sep 30, 1969|
|Claims:||1. A compound selected from the group consisting of 2-formyl-2-(6-methoxy-2-naphthyl acetic acid and the alkyl, cycloalkyl, aralkyl and alkenyl esters thereof.|
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