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Details for Patent: 3,681,432

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Details for Patent: 3,681,432

Abstract:2-(6-Methoxy-2-naphthyl)propionic acid is prepared by reacting a compound having the formula with hydrogen in the presence of a hydrogenation catalyst until a 2-(6-methoxy-2-naphthyl)propionate is formed, and hydrolyzing the ester group of the propionate. In the formula, R.sup.1 is an alkyl, cycloalkyl, aralkyl or alkenyl group and R.sup.2 is --OR.sup.3, --SR.sup.3, wherein R.sup.3, R.sup.5 and R.sup.6 each is alkyl or cycloalkyl; R.sup.4 is alkyl, cycloalkyl, aryl or aralkyl; and R.sup.5 and R.sup.6 together can be ethylene or a polymethylene group having from three to seven carbons. The product has anti-inflammatory, analgesic, and anti-pyretic activities.
Inventor(s): Nelson; Peter H. (Los Altos, CA)
Assignee: Syntex Corporation (Panama, PM)
Filing Date:Sep 30, 1969
Application Number:04/862,500
Claims:1. A compound selected from the group consisting of 2-formyl-2-(6-methoxy-2-naphthyl acetic acid and the alkyl, cycloalkyl, aralkyl and alkenyl esters thereof.
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