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Details for Patent: 3,676,480

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Details for Patent: 3,676,480

Abstract:L-.alpha.-acylhydrazino-.beta.-phenyl-propionitrile compounds useful as intermediates in the production of L-.alpha.-hydrazino-.beta.-phenyl-propionic acids. Also included are processes for preparing the compounds of this invention by aminating L-.alpha.-acylamido-.beta.-phenyl-propionitrile and processes for hydrolyzing the compounds of this invention to form L-.alpha.-hydrazino-.beta.-phenyl-propionic acid compounds.
Inventor(s): Sletzinger; Meyer (North Plainfield, NJ), Karady; Sandor (Elizabeth, NJ), Ly; Manuel G. (New Brunswick, NJ), Pines; Seemon H. (Murray Hill, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Feb 24, 1970
Application Number:05/013,770
Claims:1. A compound of the formula:


R and R.sub.1 each may be loweralkoxy, phenyloxy, benzyloxy or hydroxy;

R.sub.2 is hydrogen or loweralkyl;

R.sub.3 is --CN; and

R.sub.4 is loweralkanoyl.

2. A compound as in claim 1 wherein R and R.sub.1 are loweralkoxy, R.sub.2 is loweralkyl, R.sub.3 is -CN and R.sub.4 is acetyl.

3. A compound as in claim 1 wherein R is hydroxy, R.sub.1 is loweralkoxy, R.sub.2 is loweralkyl, R.sub.3 is --CN and R.sub.4 is acetyl.

4. A compound as in claim 1 wherein R and R.sub.1 are hydroxy, R.sub.2 is loweralkyl, R.sub.3 is --CN and R.sub.4 is acetyl.
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