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Details for Patent: 3,671,625

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Details for Patent: 3,671,625

Abstract:Bis-chromonyl compounds of the formula: ##SPC1## And therapeutically acceptable salts, esters and amides thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and each is H or halogen, lower alkyl, hydroxy, lower alkoxy, substituted lower alkyl or substituted lower alkoxy, and X is a saturated or unsaturated, substituted or unsubstituted, straight or branched polymethylene chain which may be interrupted by one or more carbocyclic rings or oxygen-containing heterocyclic rings, oxygen atoms or carbonyl groups are particularly useful for the relief and prophylaxis of asthma when mixed with bronchodilators. 14 Claims, No Drawings
Inventor(s): Roger Edward Collingwood Altounyan (Wilmslow, GB2)
Assignee: Fisons Pharmaceuticals Limited, Leicestershire, GB2 (N/A)
Filing Date:Mar 12, 1970
Application Number:05/019,119
Claims:1. A pharmaceutical composition which comprises a bronchodilator and a member selected from the group consisting of 1,3-bis(2-carboxychromon-5- yloxy)-2-hydroxypropane, a therapeutically acceptable salt thereof, a C.sub.1 to C.sub.4 alkyl ester thereof and an amide thereof with ammonia or lower alkyl amines, wherein the bronchodilator is present in an amount of 0.1 to 10 percent by weight of

2. The composition of claim 1 wherein the bis-chromonyl compound is in the

3. The composition of claim 1 wherein the bis-chromonyl compound is in the

4. The composition of claim 1 wherein the bis-chromonyl compound is in the

5. The composition of claim 1 wherein the bis-chromonyl compound is in the

6. The composition of claim 1 wherein the bronchodilator is isoprenaline

7. The composition of claim 1 comprising a solution of the active

8. The composition of claim 1 further comprising a pharmaceutically

9. The composition of claim 1 wherein the bronchodilator is selected from the group consisting of isoprenaline, adrenaline, orciprenaline,

10. The composition of claim 1, additionally containing a pharmaceutical
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