Deeper Knowledge, Faster

  • Uncover prior art in expired and abandoned patents
  • Obtain formulation and manufacturing information
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Farmers Insurance
Federal Trade Commission
Chinese Patent Office

Generated: November 23, 2017

DrugPatentWatch Database Preview

Claims for Patent: RE45313

« Back to Dashboard

Claims for Patent: RE45313

Title:Exendin variant peptides
Abstract: The present invention relates to novel peptide conjugates which have increased stability and are useful in the treatment of excess levels of blood glucose.
Inventor(s): Larsen; Bjarne Due (Roskilde, DK), Mikkelsen; Jens Damsgaard (Kgs. Lyngby, DK), Neve; Soren (Kgs. Lyngby, DK)
Assignee: Zealand Pharma A/S (Glostrup, DK)
Application Number:13/944,735
Patent Claims: 1. A peptide consisting of any one of the following sequences: a) H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala- -Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-P- ro-Ser-(Lys).sub.6-NH.sub.2 (des-Pro.sup.36-exendin-4(1-39)-Lys.sub.6-NH.sub.2) (SEQ ID NO:93), b) H-Lys.sub.6-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-G- lu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly- -Ala-Pro-Pro-Ser-(Lys).sub.6-NH.sub.2 (H-Lys.sub.6-des Pro.sup.36exendin-4(1-39)-Lys.sub.6-NH.sub.2) (SEQ ID NO: 149), c) H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala- -Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-N- H.sub.2 (H-des Pro.sup.36,Pro.sup.37,Pro.sup.38exendin-4 (1-39)-NH.sub.2) (SEQ ID NO: 132), d) H-Lys-Lys-Lys-Lys-Lys-Lys-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys- -Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-P- ro-Ser-Ser-Gly-Ala-Ser-NH.sub.2 (H-(Lys).sub.6-des Pro.sup.36,Pro.sup.37,Pro.sup.38exendin-4(1-39)-NH.sub.2), (SEQ ID NO: 134), e) H-Asn-Glu-Glu-Glu-Glu-Glu-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Le- u-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-- Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-NH.sub.2 (H-Asn-(Glu).sub.5-des Pro.sup.36,Pro.sup.37, Pro.sup.38exendin-4(1-39)-NH.sup.2) (SEQ ID NO: 137), f) H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Gl- u-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-- Ala-Ser-(Lys).sub.6-NH.sub.2 (des Pro.sup.36, Pro.sup.37,Pro.sup.38exendin-4 (1-39)-(Lys).sub.6-NH.sub.2) (SEQ ID NO: 133), g) H-(Lys).sub.6-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gl- n-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-- Ser-Ser-Gly-Ala-Ser-(Lys).sub.6-NH.sub.2 (H-(Lys).sub.6-des Pro.sup.36,Pro.sup.37, Pro.sup.38exendin-4(1-39)-(Lys).sub.6-NH.sub.2) (SEQ ID NO: 135), h) H-Asp-Glu-Glu-Glu-Glu-Glu-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys- -Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-P- ro-Ser-Ser-Gly-Ala-Ser-(Lys).sub.6-NH.sub.2 (H-Asn-(Glu).sub.5-des Pro.sup.36,Pro.sup.37,Pro.sup.38exendin-4(1-39)-(Lys).sub.6-NH.sub.2) (SEQ ID NO: 136); or a pharmaceutically acceptable salt thereof..].

.[.2. A composition comprising the peptide of claim 1 and a physiologically acceptable carrier..].

.Iadd.3. A peptide consisting of the sequence H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala- -Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-P- ro-Ser-(Lys).sub.6-NH.sub.2 (des-Pro.sup.36-exendin-4(1-39)-Lys.sub.6-NH.sub.2) (SEQ ID NO:93), or a pharmaceutically acceptable salt thereof..Iaddend.

.Iadd.4. A composition comprising the peptide of claim 3 and a physiologically acceptable carrier..Iaddend.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving leading biopharmaceutical companies globally:

Farmers Insurance
Johnson and Johnson
Fish and Richardson
US Army
Queensland Health

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:

Google Plus