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Last Updated: September 21, 2021

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Claims for Patent: RE41920


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Summary for Patent: RE41920
Title:Isobutylgaba and its derivatives for the treatment of pain
Abstract:The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy.
Inventor(s): Singh; Lakhbir (Cambridgeshire, GB)
Assignee: Warner-Lambert Company LLC (New York, NY)
Application Number:11/983,750
Patent Claims: 1. A method for treating pain comprising administering a therapeutically effective amount of a compound of Formula I ##STR00002## or a pharmaceutically acceptable salt, diastereomer, or enantiomer thereof wherein R.sub.1 is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or cycloalkyl of from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl, or carboxyl to a mammal in need of said treatment..].

2. A method .[.according to claim 1.]. .Iadd.for treating pain comprising administering a therapeutically effective amount of a compound of Formula I ##STR00003## or a pharmaceutically acceptable salt thereof, .Iaddend..[.wherein the compound administered is a compound of Formula I.]. wherein R.sub.3 and R.sub.2 are hydrogen, and R.sub.1 is .[.--(CH.sub.2).sub.0-2--i C.sub.4H.sub.9.]. .Iadd.isobutyl .Iaddend.as an .[.(R),.]. (S).[., or (R,S).]. isomer.Iadd., to a mammal in need of said treatment.Iaddend..

.[.3. A method according to claim 1 wherein the compound administered is named (S)-3-(aminomethyl)-5-methylhexanoic acid and 3-aminomethyl-5-methylhexanoic acid..].

4. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is inflammatory pain.

5. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is neuropathic pain.

6. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is cancer pain.

7. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is postoperative pain.

8. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is phantom .[.limit.]. .Iadd.limb .Iaddend.pain.

9. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is .[.bum.]. .Iadd.burn .Iaddend.pain.

10. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is gout pain.

11. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is osteoarthritic pain.

12. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is trigeminal neuralgia pain.

13. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is acute herpetic and postherpetic pain.

14. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is causalgia pain.

15. A method according to claim .[.1.]. .Iadd.2 .Iaddend.wherein the pain treated is idiopathic pain.

.Iadd.16. A method for treating pain comprising administering a therapeutically effective amount of (S)-3-(aminomethyl)-5-methylhexanoic acid, or a pharmaceutically acceptable salt thereof, to a human in need of said treatment..Iaddend.

.Iadd.17. A method according to claim 16 wherein the compound administered is (S)-3-(aminomethyl)-5-methylhexanoic acid..Iaddend.

.Iadd.18. A method according to claim 16 wherein the compound administered is a pharmaceutically acceptable salt of (S)-3-(aminomethyl)-5-methylhexanoic acid..Iaddend.

.Iadd.19. A method according to claim 17 wherein the pain treated is chronic pain..Iaddend.

.Iadd.20. A method according to claim 17 wherein the pain treated is selected from the group consisting of inflammatory pain, neuropathic pain, cancer pain, postoperative pain, and idiopathic pain..Iaddend.

.Iadd.21. A method according to claim 17 wherein the pain treated is neuropathic pain..Iaddend.

.Iadd.22. A method according to claim 17 wherein the pain treated is diabetic neuropathic pain..Iaddend.

.Iadd.23. A method according to claim 17 wherein the pain treated is acute herpetic pain..Iaddend.

.Iadd.24. A method according to claim 17 wherein the pain treated is postherpetic pain..Iaddend.

.Iadd.25. A method according to claim 17 wherein the pain treated is fibromyalgia pain..Iaddend.

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