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Last Updated: March 29, 2024

Claims for Patent: 9,539,310


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Summary for Patent: 9,539,310
Title:Treatment of short bowel syndrome patients with colon-in-continuity
Abstract: Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as teduglutide.
Inventor(s): Sanguinetti; Elizabeth L. (Salt Lake City, UT), Marriott; Thomas B. (Sandy, UT), Lopansri; Jennifer (Park City, UT), Blosch; Consuelo M. (Seattle, WA)
Assignee: NPS PHARMACEUTICALS, INC. (Bedminster, NJ)
Application Number:15/285,934
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,539,310
Patent Claims: 1. A method of decreasing fecal wet weight of a patient having short bowel syndrome, who receives parenteral nutrition each week, and who presents with colon-in-continuity with remnant small intestine, said method comprising administering [Gly2]hGLP-2 to said patient using a dosing regimen effective to decrease the fecal wet weight of said patient compared to fecal wet weight of said patient before said dosing regimen.

2. The method as defined in claim 1, wherein the [Gly2]hGLP-2 is administered at a daily dose of from 5 to 500 .mu.g/kg.

3. The method as defined in claim 2, wherein the [Gly2]hGLP-2 is administered at a daily dose of from 30 to 150 .mu.g/kg.

4. The method as defined in claim 1, wherein the [Gly2]hGLP-2 is administered by subcutaneous injection.

5. The method as defined in claim 4, wherein the subcutaneous injection is into the abdomen, thigh, or arm.

6. The method as defined in claim 1, wherein the patient is an adult.

7. The method as defined in claim 1, wherein said fecal wet weight is decreased by at least 5% as compared to fecal wet weight of said patient before said dosing regimen.

8. The method as defined in claim 7, wherein said fecal wet weight is decreased by at least 10% as compared to fecal wet weight of said patient before said dosing regimen.

9. The method as defined in claim 8, wherein said fecal wet weight is decreased by at least 15% as compared to fecal wet weight of said patient before said dosing regimen.

10. The method as defined in claim 9, wherein said fecal wet weight is decreased by at least 20% as compared to fecal wet weight of said patient before said dosing regimen.

11. The method as defined in claim 1, wherein said regimen comprises administration of said [Gly2]hGLP-2 over a period of at least 21 days.

12. The method as defined in claim 1, wherein said patient is an adult and the [Gly2]hGLP-2 is administered at a daily dose of from 30 to 150 .mu.g/kg by subcutaneous injection.

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