.

Deeper Knowledge, Faster

  • Plan your formulary budget
  • Analyze global market entry opportunities
  • Obtain formulation and manufacturing information

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Healthtrust
Medtronic
Mallinckrodt
Covington
Julphar
Teva
Merck
US Army
Farmers Insurance
Novartis

Generated: July 26, 2017

DrugPatentWatch Database Preview

Claims for Patent: ► Subscribe

« Back to Dashboard

Claims for Patent: ► Subscribe

Title:Methods for treating heartburn, gastric bleeding or hemorrhage in patients receiving clopidogrel therapy
Abstract: The present invention relates to methods of treating heartburn in a patient receiving clopidogrel therapy. In another aspect, the present invention relates to methods of preventing gastric bleeding or hemorrhage in patients receiving clopidogrel therapy.
Inventor(s): Lee; Ronald D. (Round Lake Beach, IL)
Assignee: Takeda Pharmaceuticals U.S.A., Inc. (Deerfield, IL)
Application Number:13/411,701
Patent Claims: 1. A method of treating heartburn or erosive esophagitis and at least one second disease state in a patient in need of treatment thereof, the method comprising: a) identifying a patient suffering from heartburn or erosive esophagitis and at least one second disease state, wherein said patient is being treated with or about to be treated with clopidrogel to treat the second disease state; b) preferentially selecting dexlansoprazole from a group of proton pump inhibitors to administer to the patient; and c) concomitantly administering separate dosage forms of clopidogrel and a therapeutically effective amount of dexlansoprazole to said patient in need of treatment thereof; wherein the therapeutically effective amount of dexlansoprazole is a dose of 60 mg.

2. The method of claim 1, wherein the heart burn is heartburn associated with symptomatic non-erosive gastroesophageal reflux disease.

3. The method of claim 1, wherein the administration of the dexlansoprazole to the patient does not inhibit CYP2C19 interactions between the dexlansoprazole and clopidogrel.

4. The method of claim 1, wherein the pharmacological activity of the clopidogrel that is administered is to concomitantly treat the at least one second disease state.

5. The method of claim 1, wherein the at least one second disease state is acute coronary syndrome, peripheral artery disease, myocardial infarction, stroke or a combination thereof.

6. A method of treating heartburn or erosive esophagitis in a patient concomitantly receiving clopidogrel without inhibiting CYP2C19 interactions between the heartburn or esophagitis treatment and clopidogrel in the patient, the method comprising the step of: preferentially administering a therapeutically effective amount of dexlansoprazole to a patient who is concomitantly receiving clopidogrel to treat heartburn or erosive esophagitis, wherein the therapeutically effective amount of dexlansoprazole does not (i) inhibit the pharmacological activity of the clopidogrel; and (ii) inhibit CYP2C19 interactions between the dexlansoprazole and the clopidogrel, wherein the therapeutically effective amount of dexlansoprazole is a dose of 60 mg.

7. The method of claim 6, wherein the heartburn is heartburn associated with symptomatic non-erosive gastroesophageal reflux disease.

8. The method of claim 6, wherein the at least one second disease state is acute coronary syndrome, peripheral artery disease, myocardial infarction, stroke or a combination thereof.

9. The method of claim 1, wherein the treatment of erosive esophagitis comprises healing erosive esophagitis.

10. The method of claim 6, wherein the treatment of erosive esophagitis comprises healing erosive esophagitis.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Colorcon
Boehringer Ingelheim
Chubb
Healthtrust
Argus Health
Fish and Richardson
McKinsey
Deloitte
US Department of Justice
US Army

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot