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|Title:||Topical dapsone and dapsone/adaplene compositions and methods for use thereof|
|Abstract:||Dapsone and dapsone/adapalene compositions can be useful for treating a variety of dermatological conditions. The compositions of this disclosure include dapsone and/or adapalene in a polymeric viscosity builder. Subject compositions can be adjusted to optimize the dermal delivery profile of dapsone to effectively treat dermatological conditions and improve the efficiency of pharmaceutical products applied to the skin. Use of the polymeric viscosity builder provides compositions with increased concentrations of diethylene glycol monoethyl ether relative to compositions without the polymeric viscosity builder.|
|Inventor(s):||Warner; Kevin S. (Anaheim, CA), Parashar; Ajay P. (San Diego, CA), Swaminathan; Vijaya (San Francisco, CA), Bhatt; Varsha (San Francisco, CA)|
|Assignee:||Allergan, Inc. (Irvine, CA)|
1. A topical pharmaceutical composition comprising: about 7.5% w/w dapsone; about 30% w/w to about 40% w/w diethylene glycol monoethyl ether; about 2% w/w to about 6% w/w
of a polymeric viscosity builder consisting of acrylamide/sodium acryloyldimethyl taurate copolymer; and water; wherein the composition does not comprise adapalene.
2. The composition of claim 1, wherein the diethylene glycol monoethyl ether is present at a concentration of about 30% w/w.
3. The composition of claim 1, wherein the polymeric viscosity builder is present at a concentration of about 4% w/w.
4. The composition of claim 1, further comprising methyl paraben.
5. A topical pharmaceutical composition comprising: about 7.5% w/w dapsone; about 30% w/w diethylene glycol monoethyl ether; about 4% w/w of a polymeric viscosity builder consisting of acrylamide/sodium acryloyldimethyl taurate copolymer; and water; wherein the composition does not comprise adapalene.
6. The composition of claim 5, further comprising methyl paraben.
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