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Serving leading biopharmaceutical companies globally:

Fish and Richardson
Boehringer Ingelheim
Covington
Queensland Health
US Army
Medtronic
UBS
Argus Health
Julphar
Cipla

Generated: January 17, 2018

DrugPatentWatch Database Preview

Claims for Patent: 8,946,207

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Summary for Patent: 8,946,207
Title:Processes for preparing 3-benzazepines
Abstract: The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
Inventor(s): Wolgast; Beverly L. (San Diego, CA), Gilson, III; Charles A. (San Diego, CA), Aytes; Shelley (San Diego, CA), Estrada; Scott A. (La Jolla, CA), Sengupta; Dipanjan (San Diego, CA), Smith; Brian (San Diego, CA), Rey; Max (Wallisellen, CH), Weigl; Ulrich (Hilzingen, DE)
Assignee: Arena Pharmaceuticals, Inc. (San Diego, CA)
Application Number:13/619,773
Patent Claims: 1. A composition comprising: a hydrochloric acid salt of a compound of Formula Va and a hydrochloric acid salt of a compound of Formula Vb, wherein the compound of Formula Va and the compound of Formula Vb have the structures, respectively, of ##STR00059## wherein R.sup.1 is H, R.sup.2 is Me, R.sup.3 is H, R.sup.4 is Cl, R.sup.5 is H, R.sup.6 is H, R.sup.8a is H, and R.sup.8b is H, and wherein the composition is enriched in the hydrochloric acid salt of the compound of Formula Vb.

2. The composition of claim 1, wherein the hydrochloric acid salt of the compound of Formula Vb is present in an enantiomeric excess of greater than about 80%.

3. The composition of claim 1, wherein the hydrochloric acid salt of the compound of Formula Vb is present in an enantiomeric excess of greater than about 90%.

4. The composition of claim 1, wherein the hydrochloric acid salt of the compound of Formula Vb is present in an enantiomeric excess of greater than about 95%.

5. The composition of claim 1, wherein the hydrochloric acid salt of the compound of Formula Vb is present in an enantiomeric excess of greater than about 98%.

6. The composition of claim 1, wherein the hydrochloric acid salt of the compound of Formula Vb is present in an enantiomeric excess of greater than about 99%.

7. The composition of claim 1, wherein the composition further comprises acetone.

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Serving leading biopharmaceutical companies globally:

US Army
McKesson
Johnson and Johnson
Healthtrust
Accenture
Baxter
Medtronic
McKinsey
Teva

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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