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Last Updated: April 23, 2024

Claims for Patent: 8,791,097

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Summary for Patent: 8,791,097

Title:	Anti-tumor activity of CCI-779 in papillary renal cell cancer
Abstract:	This invention provides the method or use of CCI-779 in the treatment of papillary renal cell carcinoma.
Inventor(s):	Dukart; Gary (Ambler, PA), Gibbons, Jr.; James Joseph (Westwood, NJ), Berkenblit; Anna (Needham, MA), Feingold; Jay Marshall (Wynnewood, PA)
Assignee:	Wyeth LLC (New York, NY)
Application Number:	12/099,394
Patent Claims:	1. A method of treating papillary renal cell carcinoma in a mammal in need thereof, which comprises providing to said mammal an effective amount of CCI-779, wherein said papillary renal cell carcinoma is metastatic. 2. The method according to claim 1, wherein the papillary renal cell carcinoma is hereditary type I papillary renal cell carcinoma. 3. The method according to claim 1, wherein the papillary renal cell carcinoma is hereditary type II papillary renal cell carcinoma. 4. The method according to claim 1, wherein the papillary renal cell carcinoma is sporadic papillary renal cell carcinoma. 5. The method according to claim 1, wherein the papillary renal cell carcinoma is previously untreated papillary renal cell carcinoma. 6. The method according to claim 1, wherein the papillary renal cell carcinoma is advanced. 7. The method according to claim 1, wherein the CCI-779 is administered intravenously. 8. The method according to claim 1, wherein the CCI-779 is administered weekly for one to 24 months. 9. The method according to claim 1, wherein the CCI-779 is administered intravenously at a dose of 1 to 250 mg per week. 10. The method according to claim 9, wherein the CCI-779 is administered intravenously at a dose of 25 mg per week. 11. The method according to claim 1, wherein the CCI-779 is the sole anti-neoplastic agent in the regimen. 12. The method according to claim 1, wherein the CCI-779 is the sole active agent in the regimen. 13. The method according to claim 1, further comprising a further active agent, provided that the further active agent is not an interferon. 14. A method of treating papillary renal cell carcinoma in a mammal in need thereof, which comprises providing to said mammal an effective amount of CCI-779 in the absence of interferon alpha.

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