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Claims for Patent: 8,645,160

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Claims for Patent: 8,645,160

Title:Methods for delivering a drug to a hospital patient for short-term use while minimizing long-term use of the drug
Abstract: Novel methods for delivering a drug to hospital patients for short-term in-hospital use while minimizing long-term use of the drug. Embodiments are provided in which hospitals are identified which may be eligible to treat patients, for example, perform certain types of surgery, and which have measures in place to limit use of the drug to short-term use. The identified hospitals are preferably registered in a storage medium, including computer readable storage media, and may be authorized to receive the shipments of the drug. The received drug may then be dispensed to the patient.
Inventor(s): Maurer; George Raymond (Dunellen, NJ), Jones; Robert Barnett (Summit, NJ)
Assignee: Adolor Corporation (
Application Number:13/541,628
Patent Claims: 1. A method of treating a subject undergoing abdominal surgery, comprising orally administering to the subject a composition comprising about 12 mg of alvimopan less than one day prior to surgery followed by administering the alvimopan composition to the subject twice daily beginning the day after surgery, wherein the method is carried out in a hospital that has acknowledged that: (i) hospital staff who prescribe, dispense or administer the alvimopan composition have been provided education materials on the need to limit the use of the alvimopan composition to short-term, inpatient use; (ii) the subject will not receive more than 15 total doses of the alvimopan composition; and (iii) the alvimopan composition will not be dispensed to the subject after being discharged from the hospital.

2. The method of claim 1, wherein short-term use comprises administration of the alvimopan to the subject for no more than 7 days following the surgery.
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