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Claims for Patent: 8,476,425

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Claims for Patent: 8,476,425

Title:Tazobactam arginine compositions
Abstract: This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions.
Inventor(s): Lai; Jan-Ji (Westborough, MA), Gu; Jian-Qiao (Lexington, MA), Pathare; Pradip M. (Lexington, MA), Jurkauskas; Valdas (Cambridge, MA), Terracciano; Joseph (Concord, MA), Damour; Nicole Miller (Belmont, MA)
Assignee: Cubist Pharmaceuticals, Inc. (Lexington, MA)
Application Number:13/628,742
Patent Claims: 1. A composition comprising crystalline tazobactam arginine characterized by an X-ray powder diffraction pattern having peaks expressed in degrees 2-Theta.+-.0.2.degree. at angles of 4.8.degree., 8.9.degree., 11.3.degree., 14.9.degree., 18.0.degree., 19.4.degree., 21.3.degree., 22.8.degree. and 24.3.degree..

2. The composition of claim 1, further characterized by a differential scanning calorimetry thermogram having a characteristic peak expressed in units of .degree. C. at a temperature in the range of about 209.2 to about 211.9.

3. The composition of claim 1, further characterized by a thermogravimetry curve with an onset temperature of about 201.9.degree. C.
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