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Summary for Patent: 8,476,425
|Title:||Tazobactam arginine compositions|
|Abstract:||This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions.|
|Inventor(s):||Lai; Jan-Ji (Westborough, MA), Gu; Jian-Qiao (Lexington, MA), Pathare; Pradip M. (Lexington, MA), Jurkauskas; Valdas (Cambridge, MA), Terracciano; Joseph (Concord, MA), Damour; Nicole Miller (Belmont, MA)|
|Assignee:||Cubist Pharmaceuticals, Inc. (Lexington, MA)|
1. A composition comprising crystalline tazobactam arginine characterized by an X-ray powder diffraction pattern having peaks expressed in degrees
2-Theta.+-.0.2.degree. at angles of 4.8.degree., 8.9.degree., 11.3.degree., 14.9.degree., 18.0.degree., 19.4.degree., 21.3.degree., 22.8.degree. and 24.3.degree..
2. The composition of claim 1, further characterized by a differential scanning calorimetry thermogram having a characteristic peak expressed in units of .degree. C. at a temperature in the range of about 209.2 to about 211.9.
3. The composition of claim 1, further characterized by a thermogravimetry curve with an onset temperature of about 201.9.degree. C.
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