|Title:||Rapidly disintegrable tablet containing polyvinyl alcohol|
|Abstract:||The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.|
|Inventor(s):|| Morita; Yutaka (Saitama, JP), Yasui; Masanobu (Saitama, JP), Ohwaki; Takayuki (Saitama, JP), Tsushima; Yuki (Saitama, JP) |
|Assignee:|| Eisai R&D Management Co., Ltd. (Tokyo, JP) |
1. A quickly disintegrating tablet comprising a medicine, mannitol and polyvinyl alcohol, wherein the medicine is famotidine, midodrine hydrochloride, brotizolam or
donepezil hydrochloride, said quickly disintegrating tablet is compressed, said tablet quickly disintegrates in an oral cavity, a compounding ratio of the mannitol is 0.8 part by weight or more to one part by weight of the tablet, and a compounding ratio
of the polyvinyl alcohol is 0.0001 to 0.1 parts by weight to one part by weight of the tablet.
2. The quickly disintegrating tablet according to claim 1, wherein the medicine is donepezil hydrochloride.
3. A method of administering a medicine, said method comprising orally administering a medicine in the form of the quickly disintegrating tablet of claim 1 to a patient in need thereof.