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|Title:||GH secretagogues and uses thereof|
|Abstract:||The invention relates to use of a GH secretagogue (e.g. GRF or an analog thereof) for (1) altering a lipid parameter in a subject; (2) altering a body composition parameter in a subject, (3) treating a condition characterized by deficient or decreased bone formation in a subject (4) improving daytime vigilance and/or cognitive function in a subject, (5) improving a metabolic condition in a subject, (6) improving anabolism in a catabolic condition in a subject, and/or (7) improving and/or reconstituting immune function in a subject.|
|Inventor(s):||Abribat; Thierry (St-Foy-les-Lyon, FR), De Villers; Andre (Outremont, CA), Allas; Soraya (Iles Des Soeurs, CA), Gravel; Denis (Saint-Lambert, CA), Chapdelaine; Alcide (Iles Des Soeurs, CA)|
|Assignee:||Theratechnologies Inc. (Ville Saint-Laurent, CA)|
1. A method of treating HIV-related lipodystrophy in a subject, said method comprising administering to said subject (hexenoyl trans-3)hGRF(1-44)NH.sub.2 (SEQ ID NO: 7), to
treat said HIV-related lipodystrophy.
2. The method of claim 1, wherein said treating HIV-related lipodystrophy comprises treating visceral fat accumulation.
3. The method of claim 1, wherein said subject is receiving antiviral therapy.
4. The method of claim 1, wherein said (hexenoyl trans-3)hGRF(1-44)NH.sub.2 (SEQ ID NO: 7) is administered at a dose selected from the group consisting of about 1 mg and about 2 mg.
5. The method of claim 1, wherein said (hexenoyl trans-3)hGRF(1-44)NH.sub.2 (SEQ ID NO: 7) is administered by a route selected from the group consisting of intravenous, oral, transdermal, subcutaneous, mucosal, intramuscular, intranasal, intrapulmonary, parenteral, intrarectal and topical.
6. The method of claim 5, wherein said (hexenoyl trans-3)hGRF(1-44)NH.sub.2 (SEQ ID NO: 7) agent is administered by a subcutaneous route.
7. The method of claim 4, wherein said (hexenoyl trans-3)hGRF(1-44)NH.sub.2 (SEQ ID NO: 7) is administered at a dose of about 2 mg.
8. The method of claim 6, wherein said (hexenoyl trans-3)hGRF(1 -44)NH.sub.2 (SEQ ID NO: 7) is administered at a dose of about 2 mg.
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