Claims for Patent: 7,211,600

Summary for Patent: 7,211,600

Title:	Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
Abstract:	The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity c-kit kinase.
Inventor(s):	Lipson; Ken (San Mateo, CA), McMahon; Gerald (Kenwood, CA)
Assignee:	Sugen Inc. (South San Francisco, CA)
Application Number:	11/205,474
Patent Claims:	1. A method for treating an abnormal condition associated with an aberration in a signal transduction pathway mediated by a c-kit kinase in an organism, comprising administering to said organism a therapeutically effective amount of an indolinone compound of the following formula that inhibits, in vitro, the catalytic activity of c-kit kinase: ##STR00020## wherein the abnormal condition is one or more gastrointestinal stromal tumors. 2. A method for treating an abnormal condition associated with an aberration in a signal transduction pathway mediated by a c-kit kinase in an organism, comprising administering to said organism a therapeutically effective amount of an indolinone compound of the following formula that inhibits, in vitro, the catalytic activity of c-kit kinase: ##STR00021## wherein the abnormal condition is mastocytosis. 3. A method for treating an abnormal condition associated with an aberration in a signal transduction pathway mediated by a c-kit kinase in an organism, comprising administering to said organism a therapeutically effective amount of an indolinone compound that inhibits, in vitro, the catalytic activity of c-kit kinase selected from the group consisting of: ##STR00022## wherein the abnormal condition is allergy-associated chronic rhinitis, inflammation or asthma. 4. A method for treating an abnormal condition associated with an aberration in a signal transduction pathway mediated by a c-kit kinase in an organism, comprising administering to said organism a therapeutically effective amount of an indolinone compound of the following formula that inhibits, in vitro, the catalytic activity of c-kit kinase: ##STR00023## wherein the abnormal condition is one or more mast cell tumors.