Generated: April 25, 2017
|Title:||Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments|
|Abstract:||According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (% w) water, usually below about 5% w and preferably less than about 3% w; a particle size of about 1.0-5.0 .mu.m mass median diameter (MMD), usually 1.0-4.0 .mu.m MMD, and preferably 1.0-3.0 .mu.m MMD; a delivered dose of about >30%, usually >40%, preferably >50%, and most preferred >60%; and an aerosol particle size distribution of about 1.0-5.0 .mu.m mass median aerodynamic diameter (MMAD), usually 1.5-4.5 .mu.m MMAD, and preferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity.|
|Inventor(s):||Platz; Robert M. (Half Moon Bay, CA), Patton; John S. (San Carlos, CA), Foster; Linda (Sunnyvale, CA), Eljamal; Mohammed (San Jose, CA)|
|Assignee:||Inhale Therapeutic Systems, Inc. (San Carlos, CA)|
1. Biocompatible particles for delivery of a therapeutic, prophylactic or diagnostic agent to the pulmonary system; wherein the particles have a tap density of less than
0.4 g/cm.sup.3 , the particle size is less thatn 10 .mu.m , and the particles have a mean aerodynamic diameter between about 1 .mu.m and about 5 .mu.m.
2. The particles of claim 1, wherein 90% of the particlesare <5.0 .mu.m in diameter.
3. The particles of claim 1, wherein the particles have a mean aerodynamic diamter of about 1 .mu.m .
4. The particles of claim 1, wherein the agent is a protein.
5. The particles of claim 1, wherein the particles have a tap density of less than 0.34 g/cm.sup.3.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.