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Claims for Patent: 6,911,214

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Claims for Patent: 6,911,214

Title: Flavoring systems for pharmaceutical compositions and methods of making such compositions
Abstract:A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.
Inventor(s): Alani; Laman (Morris Plains, NJ), Gauwitz; Donald P. (McHenry, IL), Kaul; Dilip (Bridgewater, NJ), Lipari; John M. (Racine, WI), Ghosh; Soumojeet (Lindenhurst, IL), Marsh; Kennan C. (Lake Forest, IL), Whelan; Richard H. (Norfolk, MA), Petrossian; Vanik D. (Waban, MA)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:09/946,085
Patent Claims: 1. A flavoring system useful in a liquid pharmaceutical composition containing lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof, said system comprising: (a) sodium chloride in an amount of about 0.35% by weight; (b) sodium citrate in an amount of about 0.20% by weight; (c) saccharin sodium in an amount of about 0.40% by weight; (d) acesulfame potassium in an amount of about 0.40% by weight; (e) citric acid in an amount of about 0.11% by weight; (f) menthol crystals in an amount of about 0.05% by weight; (g) high fructose corn syrup in an amount of about 16.6% by weight; (h) peppermint oil in an amount of about 0.30% by weight; (i) vanilla flavor in an amount of about 1.25% by weight; (j) cotton candy flavor in an amount of about 1.0% by weight; (k) monoammonium glycyrrhizinate in an amount of about 0.58% by weight; and (l) glycerin in an amount of at least about 5.5% by weight and not greater than about 8.5% by weight; wherein the amounts by weight are based upon the total weight of the pharmaceutical composition.
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