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Claims for Patent: 6,828,313

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Claims for Patent: 6,828,313

Title: Use of oxandrolone in the treatment of burns and other wounds
Abstract:The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The subject invention further provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient.
Inventor(s): Fishbein; Don (Westfield, NJ)
Assignee: Savient Pharmaceuticals, Inc. (East Brunswick, NJ)
Application Number:10/011,377
Patent Claims: 1. A method of increasing the rate of healing of a skin wound in a patient suffering from a skin wound which comprises administering a therapeutically effective amount of oxandrolone to the patient.

2. A method according to claim 1 wherein the skin wound is an ulcer.

3. A method according to claim 2 wherein the ulcer is a decubitus ulcer or a diabetic ulcer.

4. A method according to claim 1 wherein the skin wound comprises a skin graft.

5. A method according to claim 1 wherein the skin wound is a burn.

6. A method according to claim 1 wherein the amount of oxandrolone is about 1-100 mg per day.

7. A method according to claim 6 wherein the amount of oxandrolone is about 80 mg per day.

8. A method according to claim 6 wherein the amount of oxandrolone is about 20 mg per day.

9. A method according to claim 6 wherein the amount of oxandrolone is about 10 mg per day.

10. A method according to claim 6 wherein the amount of oxandrolone is about 2.5 mg per day.

11. A method according to claim 1 wherein the oxandrolone is administered orally.

12. A method according to claim 1 wherein the oxandrolone is administered topically.

13. A method according to claim 1 wherein the oxandrolone is administered by injection.

14. A method according to claim 1 wherein the oxandrolone is in a solid dosage form.

15. A method according to claim 1 wherein the oxandrolone is in a liquid dosage form.

16. A method according to claim 1 wherein the oxandrolone is in a sustained-release formulation.

17. A method according to claim 1 wherein the oxandrolone is 17.alpha.-methyl-17.beta.-hydroxy-2-oxa-5.alpha.-androstan-3-one.

18. A method of increasing the rate of weight gain during the recovery phase after burn-induced weight loss in a patient having a burn wound which comprises administering a therapeutically effective amount of oxandrolone to the patient.

19. A method according to claim 18 wherein the amount of oxandrolone is about 1-100 mg per day.

20. A method according to claim 19 wherein the amount of oxandrolone is about 80 mg per day.

21. A method according to claim 19 wherein the amount of oxandrolone is about 20 mg per day.

22. A method according to claim 19 wherein the amount of oxandrolone is about 10 mg per day.

23. A method according to claim 19 wherein the amount of oxandrolone is about 2.5 mg per day.

24. A method according to claim 18 wherein the oxandrolone is administered orally.

25. A method according to claim 18 wherein the oxandrolone is administered topically.

26. A method according to claim 18 wherein the oxandrolone is administered by injection.

27. A method according to claim 18 wherein the oxandrolone is in a solid dosage form.

28. A method according to claim 18 wherein the oxandrolone is in a liquid dosage form.

29. A method according to claim 18 wherein the oxandrolone is in a sustained-release formulation.

30. A method according to claim 18 wherein the oxandrolone is 17.alpha.-methyl-17.beta.-hydroxy-2-oxa-5.alpha.-androstan-3-one.

31. A method according to claim 18 further comprising administering a protein supplement.

32. A method according to claim 18 wherein the weight comprises lean body mass.

33. A method according to claim 18 wherein the weight gained is maintained.
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