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Generated: August 21, 2017

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Title: Ophthalmic composition
Abstract:The present invention is related to an ophthalmic composition comprising ketotifen as a pharmaceutically active agent.
Inventor(s): Adam; Marcia Johanna (Gisikon, CH), Fetz; Andrea (Wetzikon, CH), Kis; Gyorgy Lajos (Triboltingen, CH)
Assignee: Novartis AG (Basel, CH)
Application Number:09/619,349
Patent Claims: 1. An ophthalmic composition consisting essentially of a ketotifen salt in a concentration of 0.01 to 0.04%, a non-ionic tonicity agent in an amount such that the total tonicity of the composition has an osmolarity in the range of 210 to 290 milliosmoles, a preservative, and water, wherein said composition has a pH of between 4.4 and 5.8.

2. The composition of claim 1 wherein the ketotifen salt is ketotifen fumarate.

3. The composition of claim 1 wherein the concentration of the ketotifen salt is 0.03 to 0.04%.

4. The composition of claim 1 wherein the non-ionic tonicity agent is glycerol.

5. The composition of claim 4 wherein the concentration of said glycerol is between 1.5 and 2.5%.

6. The composition of claim 1 wherein the preservative is benzalkonium chloride.

7. The composition of claim 1 wherein the ketotifen salt is ketotifen fumarate and the concentration of said ketotifen fumarate is between 0.03 and 0.04%, wherein the non-ionic tonicity agent is glycerol and the concentration of said glycerol is between 2 and 2.5%, and the preservative is benzalkonium chloride, wherein the concentration of said benzalkonium chloride is between 0.005 and 0.02%.

8. An ophthalmic composition consisting essentially of a ketotifen salt in a concentration of 0.01 to 0.04%, a non-ionic tonicity agent in an amount such that the total tonicity of the composition has an osmolarity in the range of 210 to 290 milliosmoles, and water, wherein said composition has a pH of between 4.4 and 5.8.

9. The composition of claim 8 wherein the ketotifen salt is ketotifen fumarate and the concentration of said ketotifen fumarate is between 0.03 and 0.04%, and wherein the non-ionic tonicity agent is glycerol and the concentration of said glycerol is between 2 and 2.5%.
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