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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
Dow
Queensland Health
Julphar
Fuji
QuintilesIMS
Cantor Fitzgerald
US Army
Teva

Generated: April 19, 2018

DrugPatentWatch Database Preview

Claims for Patent: 6,776,982

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Summary for Patent: 6,776,982
Title: Autoclavable pharmaceutical compositions containing a chelating agent
Abstract:Disclosed are ophthalmic compositions comprising ketotifen and pharmaceutically acceptable salts thereof, as well as methods for making such compositions.
Inventor(s): Kis; Gyorgy Lajos (Triboltingen, CH), Adam; Marcia Johanna (Gisikon, CH), Fetz; Andrea (Wetzikon, CH)
Assignee: Novartis AG (Basel, CH)
Application Number:10/016,361
Patent Claims: 1. An ophthalmic pharmaceutical composition consisting essentially of 0.0345% ketotifen hydrogen fumarate, 2.125% glycerol, 0.01% benzalkonium chloride and water.

2. The composition according to claim 1 wherein the pH is between about 5.18 and about 5.32.

3. The composition according to claim 1 wherein the osmolality is about 240 milliosmoles.

4. The composition according to claim 2 wherein the osmolality is about 240 milliosmoles.

5. A method for making an ophthalmic pharmaceutical composition, comprising admixing the non-aqueous components ketotifen hydrogen fumarate, glycerol, and benzalkonium chloride with water such that a final concentration of the non-aqueous components is 0.0345% ketotifen hydrogen fumarate, 2.125% glycerol, and 0.01% benzalkonium chloride.

6. The method according to claim 5 wherein the pH of the composition is between about 5.18 and about 5.32.

7. The method according to claim 5 wherein the osmolality of the composition is about 240 milliosmoles.

8. The method according to claim 6 wherein the osmolality is about 240 milliosmoles.

9. The method according to claim 5 wherein the amount of degradation products in said composition is about 0.03%.

10. The composition according to claim 1 wherein the amount of degradation products in said composition is about 0.23%.

11. The composition according to claim 1 wherein the amount of degradation products in said composition is about 0.03%.

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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Colorcon
Daiichi Sankyo
Fish and Richardson
Johnson and Johnson
McKinsey
Healthtrust
Deloitte
Argus Health

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