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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
US Department of Justice
Mallinckrodt
Teva
Harvard Business School
Baxter
Johnson and Johnson
AstraZeneca
Medtronic

Generated: April 24, 2018

DrugPatentWatch Database Preview

Claims for Patent: 6,528,678

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Summary for Patent: 6,528,678
Title: Phosgene-free process for preparing carbamates
Abstract:A phosgene-free method for preparing a carbamate from a compound containing an amine group involves reacting the compound with an alkylating agent in the presence of carbon dioxide and cesium carbonate. A reaction can take place under standard pressure and temperature conditions and produces carbamates in a high yield with low by-product formation.
Inventor(s): Lee; Byung H. (Kalamazoo, MI)
Assignee: Pharmacia& Upjohn Company (Kalamazoo, MI)
Application Number:10/000,756
Patent Claims: 1. A method for preparing a carbamate from a compound containing an amine group comprising reacting the compound with chloromethyl pivalate in the presence of carbon dioxide and cesium carbonate.

2. The method of claim 1, wherein said compound contains a primary amine group.

3. The method of claim 1, wherein said compound contains a secondary amine group.

4. The method of claim 1, wherein said compound is an amino acid.

5. The method of claim 1, wherein the reaction takes place in a polar aprotic solvent.

6. The method of claim 1, wherein the amino group is a piperazine group.

7. The method of claim 5, wherein the solvent is dimethyl formamide.

8. The method of claim 1, wherein the reaction takes place under standard temperature and pressure conditions.

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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Cipla
AstraZeneca
Daiichi Sankyo
QuintilesIMS
Teva
Cerilliant
UBS
Johnson and Johnson

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