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Claims for Patent: 6,521,212

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Claims for Patent: 6,521,212

Title: Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
Abstract:A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.
Inventor(s): Cloutier; Gilles (Chapel Hill, NC), Crow; James (Chapel Hill, NC), Wade; Michael (Chapel Hill, NC), Parker; Richard E. (Spring Hill, TN), Loyd; James E. (Nashville, TN)
Assignee: United Therapeutics Corporation (Silver Spring, MD)
Application Number:09/525,471
Patent Claims: 1. A method of treating peripheral vascular disease comprising administering to a mammal in need thereof by inhalation a formulation comprising a therapeutically effective amount of a benzindene prostaglandin.

2. The method of claim 1, wherein said benzindene prostaglandin is inhaled in an aerosolized form.

3. The method of claim 2, wherein said benzindene prostaglandin is UT-15.

4. The method of claim 3, wherein said aerosolized form comprises droplets less than 10 micrometers in diameter, said droplets comprising said UT-15 in a suitable pharmacologically-acceptable liquid carrier.

5. The method of claim 1, wherein the mammal is a human.

6. A method for treating pulmonary hypertension in a mammal comprising delivering to said mammal an effective amount of UT-15 or its pharmaceutically acceptable salt or ester by inhalation.

7. The method of claim 6, wherein said UT-15 is inhaled in an aerosolized form.

8. The method of claim 7, wherein said aerosolized form comprises droplets less than 10 micrometers in diameter, said droplets comprising said compound in a suitable pharmacologically-acceptable liquid carrier.

9. The method of claim 6, wherein said UT-15 is inhaled in powder form comprising particles less than 10 micrometers in diameter.

10. The method of claim 1, wherein the formulation comprises a sustained release form of a benzindene prostalandn.

11. The method of claim 6, wherein said UT-15 is a sustained release form.

12. The method of claim 1, wherein said aerosolized administration of benzindene prostaglandin has no effect on heart rate.
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