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Claims for Patent: 6,488,960

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Claims for Patent: 6,488,960

Title: Corticosteroid formulation
Abstract:The present invention pertains to a unit dose formulation comprising 0.25 to 2 mg of a corticosteroid. This small dose can be used to treat rheumatoid arthritis, especially if adapted to release at least 90% by weight of the corticosteroid, 2 to 8 hours after administration.
Inventor(s): Bardsley; Hazel Judith (Cambridge, GB)
Assignee: Arakis Ltd. (GB)
Application Number:09/936,586
Patent Claims: 1. A controlled-release formulation comprising from 0.25 mg to 2 mg of a corticosteroid selected from the group consisting of prednisone, methylprednisolone, and prednisolone, wherein said formulation is adapted to release at least 90% by weight of the corticosteroid 2 hours to 8 hours after administration.

2. The formulation according to claim 1, which comprises from 0.5 mg to 2 mg of the corticosteroid.

3. The formulation according to claim 1, which comprises from 1 mg to 1.25 mg of the corticosteroid.

4. The formulation according to claim 1, wherein the corticosteroid is prednisolone.

5. A method for the treatment of rheumatoid arthritis, wherein said method comprises administering to a patient an effective amount of a controlled-release formulation comprising from 0.25 mg to 2 mg of a corticosteroid selected from the group consisting of prednisone, methylprednisolone, and prednisolone, wherein said formulation is adapted to release at least 90% by weight of the corticosteroid 2 hours to 8 hours after administration.

6. The method according to claim 5, wherein the formulation comprises from 0.5 mg to 2 mg of the corticosteroid.

7. The method according to claim 5, wherein the formulation comprises from 1 mg to 1.25 mg of the corticosteroid.

8. The method according to claim 5, wherein the corticosteroid is prednisolone.
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