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|Title:||Transdermal therapeutic device and method with capsaicin and capsaicin analogs|
|Abstract:||Transdermal application of capsaicin (or a capsaicin analog) in a concentration from greater than about 5% to about 10% by weight has been discovered to be an extremely effective therapy for treating neuropathic pain, so long as an anesthetic, preferably by means of a transdermal patch, is administered initially to the affected area to minimize the expected side effects from subsequent capsaicin application.|
|Inventor(s):||Robbins; Wendye R. (San Mateo, CA)|
|Assignee:||The Regents of the University of California (Oakland, CA)|
1. A device for treatment of neuropathic pain in a human patient, said device comprising:
a skin-adherent patch, the patch including a reservoir comprising a therapeutic formulation whereby said formulation is continuously provided to the surface of skin for a predetermined period of time, wherein said formulation comprises capsaicin or a capsaicin analog in a total concentration from greater than about 5% to 10% by weight of the formulation, wherein a single administration of said patch affords significant relief of said neuropathic pain to said human patient for at least several weeks.
2. The device as in claim 1 wherein the formulation is therapeutically effective in treating neuropathic pain in a human patient when the area being treated has first been effectively anesthetized so as to block afferent nerve fibers.
3. The device as in claim 2 further comprising a second patch, the second patch capable of delivering an anesthetic in an amount effective to block afferent nerve fibers to the side effects of the capsaicin or capsaicin analog administered via the patch.
4. The device as in claim 1 wherein the total concentration of the capsaicin or capsaicin analog is about 7.5 weight percent to 10 weight percent.
5. The device as in claim 1, wherein said capsaicin or a capsaicin analog is capsaicin.