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|Title:||Gamma amino butyric acid analogs and optical isomers|
|Abstract:||A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.|
|Inventor(s):||Silverman; Richard B. (Morton Grove, IL), Andruszkiewicz; Ryszard (Sopot, PL)|
|Assignee:||Northwestern University (Evanston, IL)|
1. A compound of the formula S-(+)-4-amino-3-(2-methylpropyl) butanoic acid as a single optical isomer.
2. 4-amino-3-(2-methylpropyl) butanoic acid, or a pharmaceutically acceptable salt thereof.
3. A pharmaceutically acceptable salt of S-(+)-(4)-amino-3-(2-methylpropyl) butanoic acid, said salt being present as a single optical isomer.
4. A pharmaceutical composition comprising a compound any one of claims 1 or 3, together with a pharmaceutically acceptable carrier.
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