Last Updated: June 9, 2026

Claims for Patent: 6,001,876

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Summary for Patent: 6,001,876

Title:	Isobutylgaba and its derivatives for the treatment of pain
Abstract:	The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy.
Inventor(s):	Lakhbir Singh
Assignee:	Warner Lambert Co LLC
Application Number:	US09/043,358
Patent Claims:	1. A method for treating pain comprising administering a therapeutically effective amount of a compound of Formula I ##STR2## or a pharmaceutically acceptable salt, diastereomer, or enantiomer thereof whereinR1 is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or cycloalkyl of from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl, or carboxyl to a mammal in need of said treatment. 2. A method according to claim 1 wherein the compound administered is a compound of Formula I wherein R3 and R2 are hydrogen, and R1 is --(CH2)0-2 --i C4 H9 as an (R), (S), or (R,S) isomer. 3. A method according to claim 1 wherein the compound administered is named (S)-3-(aminomethyl)-5-methylhexanoic acid and 3-aminomethyl-5-methyl-hexanoic acid. 4. A method according to claim 1 wherein the pain treated is inflammatory pain. 5. A method according to claim 1 wherein the pain treated is neuropathic pain. 6. A method according to claim 1 wherein the pain treated is cancer pain. 7. A method according to claim 1 wherein the pain treated is postoperative pain. 8. A method according to claim 1 wherein the pain treated is phantom limit pain. 9. A method according to claim 1 wherein the pain treated is bum pain. 10. A method according to claim 1 wherein the pain treated is gout pain. 11. A method according to claim 1 wherein the pain treated is osteoarthritic pain. 12. A method according to claim 1 wherein the pain treated is trigeminal neuralgia pain. 13. A method according to claim 1 wherein the pain treated is acute herpetic and postherpetic pain. 14. A method according to claim 1 wherein the pain treated is causalgia pain. 15. A method according to claim 1 wherein the pain treated is idiopathic pain.

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