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Claims for Patent: 6,001,876

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Claims for Patent: 6,001,876

Title: Isobutylgaba and its derivatives for the treatment of pain
Abstract:The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy.
Inventor(s): Singh; Lakhbir (Cambridgeshire, GB)
Assignee: Warner-Lambert Company (Morris Plains, NJ)
Application Number:09/043,358
Patent Claims: 1. A method for treating pain comprising administering a therapeutically effective amount of a compound of Formula I ##STR2## or a pharmaceutically acceptable salt, diastereomer, or enantiomer thereof wherein

R.sub.1 is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or cycloalkyl of from 3 to 6 carbon atoms;

R.sub.2 is hydrogen or methyl; and

R.sub.3 is hydrogen, methyl, or carboxyl to a mammal in need of said treatment.

2. A method according to claim 1 wherein the compound administered is a compound of Formula I wherein R.sub.3 and R.sub.2 are hydrogen, and R.sub.1 is --(CH.sub.2).sub.0-2 --i C.sub.4 H.sub.9 as an (R), (S), or (R,S) isomer.

3. A method according to claim 1 wherein the compound administered is named (S)-3-(aminomethyl)-5-methylhexanoic acid and 3-aminomethyl-5-methyl-hexanoic acid.

4. A method according to claim 1 wherein the pain treated is inflammatory pain.

5. A method according to claim 1 wherein the pain treated is neuropathic pain.

6. A method according to claim 1 wherein the pain treated is cancer pain.

7. A method according to claim 1 wherein the pain treated is postoperative pain.

8. A method according to claim 1 wherein the pain treated is phantom limit pain.

9. A method according to claim 1 wherein the pain treated is bum pain.

10. A method according to claim 1 wherein the pain treated is gout pain.

11. A method according to claim 1 wherein the pain treated is osteoarthritic pain.

12. A method according to claim 1 wherein the pain treated is trigeminal neuralgia pain.

13. A method according to claim 1 wherein the pain treated is acute herpetic and postherpetic pain.

14. A method according to claim 1 wherein the pain treated is causalgia pain.

15. A method according to claim 1 wherein the pain treated is idiopathic pain.
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