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Generated: September 24, 2017

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Title: 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1- cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
Abstract:The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4 -oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid represent by the following formula: ##STR1## or its isomer.
Inventor(s): Hong; Chang Yong (Daejeon, KR), Kim; Young Kwan (Daejeon, KR), Kim; Se Ho (Daejeon, KR), Chang; Jay Hyok (Daejeon, KR), Choi; Hoon (Daejeon, KR), Nam; Do Hyun (Daejeon, KR), Kim; Ae Ri (Daejeon, KR), Lee; Jin Hwa (Daejeon, KR), Park; Ki Sook (Daejeon, KR)
Assignee: LG Chemical Ltd. (Seoul, KR)
Application Number:09/188,063
Patent Claims: 1. A method for prophylaxis or treatment of bacterial infections in a warm blooded animal, comprising administering an effective amount of the compound 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4 -oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid of the following formula: ##STR269## or a pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, or isomer thereof.

2. The method according to claim 1 wherein the compound is in the form of Z-isomer.

3. The method according to claim 1 wherein the compound is administered once a day.

4. The method according to claim 1 wherein the warm blooded mammal is a human being.

5. A method for prophylaxis or treatment of bacterial infections in a warm blooded animal, comprising administering 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4 -oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate or a hydrate thereof of the following formula: ##STR270## in which n is 0, 1, 1.5, 2.5, 3, 3.5 or 4, or an isomer thereof.

6. The method according to claim 5 wherein the compound is in the form of Z-isomer.

7. The method according to claim 5 wherein n is 3.

8. The method according to claim 5 wherein the compound has a moisture content of from 9 to 11% by weight.

9. The method according to claim 5 wherein n is 1.5.

10. The method according to claim 5 wherein the compound has a moisture content of from 4 to 6% by weight.

11. The method according to claim 5 wherein the compound is administered once a day.

12. The method according to claim 5 wherein the warm blooded animal is a human being.
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Covington
Queensland Health
Julphar
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Federal Trade Commission
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Medtronic
McKesson
Mallinckrodt

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