|Title:|| Recombinant heterodimeric human fertility hormones, and methods, cells, and vectors and DNA for the production thereof|
|Abstract:||Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.|
|Inventor(s):|| Reddy; Vermuri B. (Westboro, MA), Hsiung; Nancy (Wellesley, MA), Beck; Anton K. (Grisbeladierbeg, CH), Bernstine; Edward George (Boston, MA) |
|Assignee:|| Genzyme Corporation (Cambridge, MA) |
1. A recombinantly produced biologically active heterodimeric human fertility hormone selected from the group consisting of human chorionic gonadotropin, human luteinizing hormone, and
human follicle stimulating hormone, free from contamination by any other proteins of human origin.
2. A recombinantly produced hormone in accordance with claim 1, wherein said hormone is human chorionic gonadotropin.
3. A recombinantly produced hormone in accordance with claim 1, wherein said hormone is human luteinizing hormone.
4. A recombinantly produced hormone in accordance with claim 1, wherein said hormone is human follicle stimulating hormone.