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Claims for Patent: 5,684,016

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Claims for Patent: 5,684,016

Title: Method of treating cardiac insufficiency
Abstract:The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
Inventor(s): Henning; Rainer (Hattersheim am Main, DE), Urbach; Hansjorg (Kronberg/Taunus, DE), Teetz; Volker (Hofheim am Taunus, DE), Geiger; Rolf (Frankfurt am Main, DE), Scholkens; Bernward (Kelkheim, DE)
Assignee: Hoechst Aktiengesellschaft (DE)
Application Number:08/445,543
Patent Claims: 1. A method of treating cardiac insufficiency in a mammal comprising the step of administering to a mammal in recognized need of, and for the purpose of said treatment, an amount of an angiotensin-converting enzyme inhibitor effective for said treatment, said angiotensin-converting enzyme inhibitor having the formula Ia ##STR6## in which R.sup.2 and R.sup.3 are identical or different and are selected from hydrogen, (C.sub.1 -C.sub.6)-alkyl and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkyl or a pharmaceutically acceptable salt thereof.

2. A method in accordance with claim 1, in which R.sup.2 and R.sup.3 are identical or different and are selected from hydrogen and (C.sub.1 -C.sub.6)-alkyl.

3. A method in accordance with claim 1, in which R.sup.2 and R.sup.3 are identical or different and are selected from hydrogen, (C.sub.1 -C.sub.4)-alkyl and benzyl.

4. The method of claim 1, wherein said inhibitor or salt thereof is administered orally or parenterally.

5. The method of claim 1, wherein said inhibitor or salt thereof is administered in combination with a pharmaceutically suitable excipient or acceptable organic or inorganic substance.

6. A method of treating cardiac insufficiency in a mammal comprising the step of administering to a mammal in recognized need of, and for the purpose of said treatment, an amount of an angiotensin-converting enzyme inhibitor effective for said treatment, said angiotensin-converting enzyme inhibitor being N-(1-S-carbethoxy-3-phenyl-propyl)-S-alanyl-S-1,2,3,4-tetrahydroisoquinoli ne-3-carboxylic acid or a pharmaceutically acceptable salt thereof.
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