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|Title:||Methods and compositions for inhibition of angiogenesis|
|Abstract:||The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.|
|Inventor(s):||D'Amato; Robert (Lancaster, PA)|
|Assignee:||Childrens Hospital Medical Center Corp. (Boston, MA)|
1. A method of treating undesired angiogenesis in a human or animal comprising, administering to the human or animal with the undesired angiogenesis a composition comprising an
angiogenesis-inhibiting amount of thalidomide.
2. The method of claim 1, wherein the composition further comprises an epoxide hydrolase inhibitor.
3. The method of claim 1, wherein the undesired angiogenesis is associated with corneal neovascularization.