Find generic entry opportunities
Proactively manage your pharmacy inventory
Manage your formulary budget
Anticipate generic drug launch
Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Drug patents …
… from Kazakhstan to Kalamazoo
Flat-rate pricing for predictable budgeting
Short-term plans for project- or client-based billing
Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Asp.sup.B28 insulin crystals|
|Abstract:||The present invention relates to insulin crystals comprising ASP.sup.B28 and protamine, and pharmaceutical preparations containing same. The crystals and preparations exhibit rapid onset and prolonged activity when administered in vivo.|
|Inventor(s):||Balschmidt; Per (Esper.ae butted.rde, DK)|
|Assignee:||Novo Nordisk A/S (Basgsvaerd, DK)|
1. Crystals comprising Ash.sup.B28 human insulin and protamine.
2. Crystals, according to claim 1, comprising zinc.
3. Crystals according to claim 2, comprising from about 0.35 to about 1.5, preferably from about 0.5 to about 1, % (weight/weight) zinc.
4. Crystals according to claim 1, comprising from about 10 to about 15, preferably from about 12.5 to about 14, % (weight/weight) of protamine.
5. A preparation comprising crystals according to claim 1, suspended in an aqueous medium.
6. A preparation according to claim 5, comprising zinc.
7. A preparation according to claim 5, wherein the content of Asp.sup.B28 human insulin is in the range from about 10 through about 500 IU/ml, preferably in the range from about 20 through about 200 IU/ml, most preferred in the range from about 40 through about 100 IU/ml.
8. Protamine zinc insulin preparation according to claim 5, wherein the content of zinc is in the range from about 0.3 .mu.g through about 2 .mu.g zinc per IU of Asp.sup.B28 human insulin.
9. A preparation according to claim 5, having a pH value in the range from about 6.5 through about 8, preferably in the range from about 7 through about 7.5, most preferred in the range from about 7.2 through about 7.4.
10. A preparation according to claim 5 comprising dissolved Asp.sup.B28 human insulin.
11. A preparation according to claim 10, wherein the ratio between crystals comprising Asp.sup.B28 human insulin and protamine, on one hand, and dissolved Asp.sup.B28 human insulin, on the other hand, is in the range from about 90:10 to about 50:50, preferably about 70:30.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.