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Claims for Patent: 5,435,076

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Claims for Patent: 5,435,076

Title: Injection device
Abstract:A device for an injection apparatus, including a dual-chamber injection cartridge. The cartridge includes a front end, a rear end, a front opening in the vicinity of a front end of the cartridge, a front chamber located in the vicinity of the front opening and including a drug freeze-dried in the front chamber, a rear chamber including a liquid component, a movable wall separating the front chamber and the rear chamber, a bypass for transferring the liquid component between the front chamber and the rear chamber, and a rear piston. The cartridge is slidably arranged within a cylindrical sleeve substantially the same length as the cartridge. A stopper is located in the vicinity of the front opening of the cartridge. The stopper is directed rearwardly coaxially with the cartridge, wherein as the sleeve is displaced rearwardly after the freeze-drying of the drug, the stopper enters the front opening of the cartridge to sealingly close the cartridge. An actuator for actuating the rear piston may be attached in the vicinity of the rear end of the cartridge.
Inventor(s): Hjertman; Birger (Vallingby, SE), Levander; Gustav (Bromma, SE), Ljungquist; Olle (Taby, SE)
Assignee: Pharmacia Aktiebolag (SE)
Application Number:08/142,408
Patent Claims: 1. A device for an injection apparatus, comprising:

a dual-chamber injection cartridge, comprising:

a front end and a rear end;

a front opening in the vicinity of a front end of said cartridge;

a front chamber located in the vicinity of said front opening and including a drug freeze-dried in said front chamber,

a rear chamber including a liquid component,

a movable wall separating said front chamber and said rear chamber,

a bypass for transferring said liquid component between said front chamber and said rear chamber, and

a rear piston;

a cylindrical sleeve substantially the same length as said cartridge, said cartridge being slidably arranged within said sleeve;

a stopper located in the vicinity of said front opening of said cartridge, said stopper being directed rearwardly coaxially with said cartridge, wherein as said sleeve is displaced rearwardly after the freeze-drying of said drug said stopper enters the front opening of said cartridge to sealingly close said cartridge; and

means in the vicinity of said rear end of said cartridge for attaching means for actuating said rear piston.

2. A method for preparing an injection apparatus for dual-chamber injection cartridges, said method comprising the steps of:

providing a device for an injection apparatus, the device comprising a dual-chamber injection cartridge, including a front end, a rear end, a front chamber, a rear chamber, a movable wall separating the front chamber and the rear chamber, a bypass for transferring material between the front chamber and the rear chamber, and a piston;

providing a solution or dispersion of a component in a front chamber of the cartridge;

arranging a cylindrical sleeve around the cartridge;

providing a front end of the sleeve with a stopper, said stopper being directed rearwardly toward and coaxially with the cartridge;

inserting the cartridge into a freeze-drying apparatus;

subjecting the solution or dispersion of the component to a freeze-drying process, the freeze-drying process being carried out with the stopper in a position where a front opening of the cartridge is not sealed;

displacing the sleeve and the stopper rearwardly such that the stopper is inserted into the front opening of the cartridge to sealingly close to cartridge;

removing the sealed cartridge from the freeze-drying apparatus;

providing a liquid component in the rear chamber of the cartridge; and

providing the rear end of the sleeve with means for actuating the rear piston.

3. A device according to claim 1, characterized in that a spacing is arranged between the exterior wall of the cartridge and the interior wall of the sleeve, to afford a connection between the interior of the cartridge and the exterior environment.

4. A device according to claim 1, characterized in that openings are arranged in the sleeve near its front end, to afford a connection between the interior of the cartridge and the exterior environment.

5. A device according to claim 1, characterized in that the stopper is provided with sealing ridges which cooperate with an area in the interior wall of the cartridge near its front opening, such that the stopper does not seal completely against said area until the stopper is fully inserted.

6. A device according to claim 1, characterized in that the stopper is provided with a thinned central part, to serve as a septum for affording fluid contact with the sealed front chamber.

7. A device according to claim 1, wherein said bypass comprises an area of an interior wall of said cartridge, wherein said movable wall does not seal completely against said interior wall.

8. A method according to claim 2, wherein a protective gas is introduced into the freeze-drying apparatus before the cartridge is sealingly closed.

9. An injection apparatus, comprising:

a dual-chamber injection cartridge, comprising:

a front end and a rear end;

a front opening in the vicinity of a front end of said cartridge;

a front chamber located in the vicinity of said front opening and including a drug freeze-dried in said front chamber,

a rear chamber including a liquid component,

a movable wall separating said front chamber and said rear chamber,

a bypass for transfer,ring said liquid component between said front chamber and said rear chamber, and

a rear piston;

a cylindrical sleeve substantially the same length as said cartridge, said cartridge being slidably arranged within said sleeve;

a stopper located in the vicinity of said front opening of said cartridge, said stopper being directed rearwardly coaxially with said cartridge, wherein as said sleeve is displaced rearwardly after the freeze-drying of said drug said stopper enters the front opening of said cartridge to sealingly close said cartridge; and

means in the vicinity of said rear end of said cartridge for attaching means for actuating said rear piston.

10. An injection apparatus, prepared in accordance with claim 2.

11. A device according to claim 1, further comprising:

a spacing arranged between an exterior wall of the cartridge and an interior wall of the sleeve, said spacing providing a connection between an interior of the cartridge and an exterior environment.

12. A device according to claim 1, further comprising:

openings arranged in the sleeve in the vicinity of the front end, the openings providing a connection between an interior of the cartridge and an exterior environment.

13. A device according to claim 3, wherein the stopper includes sealing ridges that cooperate with an area in an interior wall of the cartridge in the vicinity of the front opening, such that the stopper does not completely seal said area until the stopper is fully inserted.

14. A device according to claim 4, wherein the stopper includes sealing ridges that cooperate with an area in an interior wall of the cartridge in the vicinity of the front opening, such that the stopper does not completely seal said area until the stopper is fully inserted.

15. A device according to claim 3, characterized in that the stopper is provided with a thinned central part, to serve as a septum for affording fluid contact with the sealed front chamber.

16. A device according to claim 4, characterized in that the stopper is provided with a thinned central part, to serve as a septum for affording fluid contact with the sealed front chamber.

17. A device according to claim 5, characterized in that the stopper is provided with a thinned central part, to serve as a septum for affording fluid contact with the sealed front chamber.
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