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Claims for Patent: 5,200,196

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Claims for Patent: 5,200,196

Title: Improvement in pulsed drug therapy
Abstract:A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
Inventor(s): Ayer; Atul D. (Palo Alto, CA), Theeuwes; Felix (Los Altos, CA), Wong; Patrick S. L. (Palo Alto, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:07/640,469
Patent Claims: 1. An improvement in a chronological dosage form for delivering a beneficial drug to a drug recipient, wherein the dosage form comprises:

(a) a wall comprising at least in part a composition permeable to the passage of fluid, which wall surrounds and forms;

(b) a compartment;

(c) a drug formulation in the compartment;

(d) at least one exit means in the wall for delivering the drug from the dosage form, and wherein the improvement comprises:

(e) means in the compartment for delaying the delivery of drug from the dosage form, which means comprises a drug-free 0.1 mm to 10 mm thick lamina that delays the delivery of drug for up to 12 hours and surrounds the drug formulation for providing drug at a delayed time for therapy int he recipient.
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