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|Title:||Improvement in pulsed drug therapy|
|Abstract:||A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.|
|Inventor(s):||Ayer; Atul D. (Palo Alto, CA), Theeuwes; Felix (Los Altos, CA), Wong; Patrick S. L. (Palo Alto, CA)|
|Assignee:||ALZA Corporation (Palo Alto, CA)|
1. An improvement in a chronological dosage form for delivering a beneficial drug to a drug recipient, wherein the dosage form comprises:
(a) a wall comprising at least in part a composition permeable to the passage of fluid, which wall surrounds and forms;
(b) a compartment;
(c) a drug formulation in the compartment;
(d) at least one exit means in the wall for delivering the drug from the dosage form, and wherein the improvement comprises:
(e) means in the compartment for delaying the delivery of drug from the dosage form, which means comprises a drug-free 0.1 mm to 10 mm thick lamina that delays the delivery of drug for up to 12 hours and surrounds the drug formulation for providing drug at a delayed time for therapy int he recipient.
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