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Last Updated: April 25, 2024

Claims for Patent: 4,814,470

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Summary for Patent: 4,814,470

Title:	Taxol derivatives, their preparation and pharmaceutical compositions containing them
Abstract:	Taxol derivatives of formula ##STR1## in which R represents hydrogen or acetyl, one of R.sub.1 or R.sub.2 represents hydroxy and the other represents tert-butoxycarbonylamino and their isomers are useful antitumor agents.
Inventor(s):	Colin; Michel (Thoiry, FR), Guenard; Daniel (Montrouge, FR), Gueritte-Voegelein; Francoise (Paris, FR), Potier; Pierre (Paris, FR)
Assignee:	Rhone-Poulenc Sante (Courbevoie, FR)
Application Number:	07/073,156
Patent Claims:	1. A taxol derivative of formula: ##STR7## in which R represents hydrogen or acetyl and one of R.sub.1 and R.sub.2 represents hydroxy and the other represents tert-butoxycarbonylamino, and the stereoisomeric forms thereof and their mixtures. 2. A taxol derivative according to claim 1, in which R is hydrogen, R.sub.1 is hydroxy and R.sub.2 is tert-butoxycarbonylamino, and having the 2'R, 3'S configuration. 3. A taxol derivative according to claim 1, in which R is hydrogen, R.sub.1 is hydroxy, and R.sub.2 is tert-butoxycarbonylamino, and having the 2'S, 3'R configuration. 4. A taxol derivative according to claim 1, in which R is hydrogen, R.sub.1 is tert-butoxycarbonylamino, and R.sub.2 is hydroxy, and having the 2'R, 3'S configuration. 5. A taxol derivative according to claim 1, in which R is hydrogen, R.sub.1 is tert-butoxycarbonylamino, and R.sub.2 is hydroxy and having the 2'S, 3'R configuration. 6. A pharmaceutical composition which contains a taxol derivative as claimed in claim 1 combined with one or more pharmaceutically acceptable, inert or physiologically active diluents or adjuvants.

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