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|Title:||Crystalline hydrate of oral cephalosporin and its composition|
|Abstract:||An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.|
|Inventor(s):||Hamashima; Yoshio (Kyoto, JP), Minami; Kyoji (Nara, JP), Kawata; Kyozo (Osaka, JP), Sakamoto; Teruo (Osaka, JP), Takeda; Toyohiko (Hyogo, JP), Suzuki; Yusuke (Osaka, JP), Tujikawa; Masanori (Nara, JP)|
|Assignee:||Shionogi & Co., Ltd. (Osaka, JP)|
1. A crystalline hydrate of 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid having the X-ray diffraction pattern as follows:
2. A hydrate as claimed in claim 1 that contains 7 to 14% of crystal water.
3. A hydrate as claimed in claim 1 that is dihydrate.
4. A hydrate as claimed in claim 1 that is trihydrate.
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