|Title:||Method of inhibiting blood clotting with desulfatohirudins|
|Abstract:||The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof. The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.|
|Inventor(s):||Fritz; Hans (Hohenbrunn, DE), Dodt; Johannes (Munich, DE), Seemuller; Ursula (Munich, DE), Fink; Ernst (Westerstede-Giesselhorst, DE)|
|Assignee:||Ciba-Geigy Corporation (Ardsley, NY)|
1. A method of inhibiting clotting of mammalian blood comprising contacting said blood with at least one desulfatohirudin selected from ##STR3##
2. The method of claim 1 wherein said blood is circulating within the body of the subject.
3. The method of claim 1 wherein said blood is outside of the body of the subject.