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Serving leading biopharmaceutical companies globally:

Mallinckrodt
Moodys
Farmers Insurance
McKinsey
Dow
Queensland Health
Teva
Johnson and Johnson
McKesson
Boehringer Ingelheim

Generated: November 21, 2017

DrugPatentWatch Database Preview

Claims for Patent: 4,745,177

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Claims for Patent: 4,745,177

Title: Desulfatohirudins, the preparation thereof and pharmaceutical compositions containing them
Abstract:The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof. The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.
Inventor(s): Fritz; Hans (Hoenbrunn, DE), Dodt; Johannes (Munich, DE), Seemuller; Ursula (Munich, DE), Fink; Ernst (Westerstede-Giesselhorst, DE)
Assignee: Ciba-Geigy Corporation (Ardsley, NY) Plantorgan Werk Heinrich G.E. Christensen KG (Bad Zwischenahn, DE)
Application Number:06/929,710
Patent Claims: 1. A desulfatohirudin of the formula I ##STR3## or of the formula II ##STR4## wherein the --Cys-- residues are linked in pairs by disulfide bridges in the same manner as in hirudin, or a salt thereof.

2. The desulfatohirudin according to claim 1 characterised by formula I, or a pharmaceutically acceptable salt thereof.

3. The desulfatohirudin according to claim 1 characterised by formula II, or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition containing at least one desulfatohirudin according to claim 1, or a pharmacologicallly acceptable salt thereof, optionally together with at least one pharmaceutical carrier or excipient.
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Serving leading biopharmaceutical companies globally:

Baxter
US Army
Mallinckrodt
Fish and Richardson
Healthtrust
Julphar
Chubb
Deloitte
US Department of Justice
Chinese Patent Office

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