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Serving 500+ biopharmaceutical companies globally:

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Fish and Richardson
Harvard Business School
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Generated: September 25, 2017

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Title: Desulfatohirudins, the preparation thereof and pharmaceutical compositions containing them
Abstract:The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof. The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.
Inventor(s): Fritz; Hans (Hoenbrunn, DE), Dodt; Johannes (Munich, DE), Seemuller; Ursula (Munich, DE), Fink; Ernst (Westerstede-Giesselhorst, DE)
Assignee: Ciba-Geigy Corporation (Ardsley, NY) Plantorgan Werk Heinrich G.E. Christensen KG (Bad Zwischenahn, DE)
Application Number:06/929,710
Patent Claims: 1. A desulfatohirudin of the formula I ##STR3## or of the formula II ##STR4## wherein the --Cys-- residues are linked in pairs by disulfide bridges in the same manner as in hirudin, or a salt thereof.

2. The desulfatohirudin according to claim 1 characterised by formula I, or a pharmaceutically acceptable salt thereof.

3. The desulfatohirudin according to claim 1 characterised by formula II, or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition containing at least one desulfatohirudin according to claim 1, or a pharmacologicallly acceptable salt thereof, optionally together with at least one pharmaceutical carrier or excipient.
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Serving 500+ biopharmaceutical companies globally:

Baxter
Daiichi Sankyo
Healthtrust
QuintilesIMS
Dow
US Army
Citi
Teva
Express Scripts
Moodys

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