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|Title:||Desulfatohirudins, the preparation thereof and pharmaceutical compositions containing them|
|Abstract:||The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof. The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.|
|Inventor(s):||Fritz; Hans (Hoenbrunn, DE), Dodt; Johannes (Munich, DE), Seemuller; Ursula (Munich, DE), Fink; Ernst (Westerstede-Giesselhorst, DE)|
|Assignee:||Ciba-Geigy Corporation (Ardsley, NY) Plantorgan Werk Heinrich G.E. Christensen KG (Bad Zwischenahn, DE)|
1. A desulfatohirudin of the formula I ##STR3## or of the formula II ##STR4## wherein the --Cys-- residues are linked in pairs by disulfide bridges in the same manner as in
hirudin, or a salt thereof.
2. The desulfatohirudin according to claim 1 characterised by formula I, or a pharmaceutically acceptable salt thereof.
3. The desulfatohirudin according to claim 1 characterised by formula II, or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition containing at least one desulfatohirudin according to claim 1, or a pharmacologicallly acceptable salt thereof, optionally together with at least one pharmaceutical carrier or excipient.